Evidence map›Paper›PMID 35683562›Full record

ArticleJournal of clinical medicine2022

Home-Based Adaptation to Night-Time Non-Invasive Ventilation in Patients with Amyotrophic Lateral Sclerosis: A Randomized Controlled Trial.

Eleonora Volpato, Michele Vitacca, Luciana Ptacinsky, Agata Lax, Salvatore D'Ascenzo, Enrica Bertella, Mara Paneroni, Silvia Grilli, Paolo Banfi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Enhancing respiratory function in neuromuscular disease: the role of non-invasive ventilation. A narrative review.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2024
    Review
  4. Review
  5. Review
  6. The role of telemonitoring in patients on home mechanical ventilation.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Eleonora VolpatoIRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.ORCID 0000-0003-0266-6386
Michele VitaccaIstituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation of the Institute of Lumezzane, 25065 Brescia, Italy.ORCID 0000-0002-9389-7915
Luciana PtacinskyIRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.ORCID 0000-0001-7789-9614
Agata LaxIRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.
Salvatore D'AscenzoIRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.
Enrica BertellaIstituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation of the Institute of Lumezzane, 25065 Brescia, Italy.
Mara PaneroniIstituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation of the Institute of Lumezzane, 25065 Brescia, Italy.ORCID 0000-0003-3982-2098
Silvia GrilliIRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.
Paolo BanfiIRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.ORCID 0000-0001-8162-0751
Don Carlo Gnocchi Foundation · ITIstituti Clinici Scientifici Maugeri · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInitiation to Non-Invasive Ventilation (NIV) in amyotrophic lateral sclerosis (ALS) can be implemented in an inpatient or outpatient setting.

aimsWe aimed to evaluate the efficacy of adaptation (the number of needed sessions) to home-based NIV compared to an outpatient one in ALS in terms of arterial carbon dioxide (PaCO2) improvement. NIV acceptance (mean use of ≥5 h NIV per night for three consecutive nights during the adaptation trial), adherence (night-time NIV usage for ≥150 h/month), quality of life (QoL), and caregiver burden were secondary outcomes.

methodsA total of 66 ALS patients with indications for NIV were involved in this randomized controlled trial (RCT): 34 underwent NIV initiation at home (home adaptation, HA) and 32 at multiple outpatient visits (outpatient adaptation, OA). Respiratory function tests were performed at baseline (the time of starting the NIV, T0) together with blood gas analysis, which was repeated at the end of adaptation (T1) and 2 (T2) and 6 (T3) months after T1. NIV adherence was measured at T2 and T3. Overnight cardiorespiratory polygraphy, Short Form Health Survey (SF-36), Caregiver Burden Inventory (CBI), Caregiver Burden Scale (CBS), and Zarit Burden Interview (ZBI) were performed at T0, T2, and T3.

resultsFifty-eight participants completed the study. No differences were found between groups in PaCO2 at T1 (

conclusionsIn ALS, adaptation to NIV in the patient's home is as effective as that performed in an outpatient setting regarding PaCO2, acceptance, and adherence, which emphasizes the need for further studies to understand the role of the environment concerning NIV adherence.

Indexed as

ALSamyotrophic lateral sclerosishomecareMNDmotor neuron diseaseNIVnon-invasive ventilation

Identifiers

PMID35683562
PMCPMC9181816
OpenAlexW4281933085

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.