Evidence map›Paper›PMID 35682883›Full record

ArticleInternational journal of molecular sciences2022

BIAPSS: A Comprehensive Physicochemical Analyzer of Proteins Undergoing Liquid-Liquid Phase Separation.

Aleksandra E Badaczewska-Dawid, Vladimir N Uversky, Davit A Potoyan

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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  5. International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Aleksandra E Badaczewska-DawidDepartment of Chemistry, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0003-1832-4364
Vladimir N UverskyDepartment of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-4037-5857
Davit A PotoyanDepartment of Chemistry, Iowa State University, Ames, IA 50011, USA.
Iowa State University · USUniversity of South Florida · US

Funding

Multi-scale computational investigation of functions and mechanisms of protein-RNA phase separation.R35GM138243 · NIGMS · IOWA STATE UNIVERSITY · PI Davit POTOYAN · 2020 to 2026
$2.4M
NIGMS NIH HHS R35 GM138243NIH HHS R35GM138243Roy J. Carver Charitable Trust Iowa State University Bioscience Innovation Postdoctoral Fellowship to A.E.B-D.
6 · The paper itself

Abstract

The liquid-liquid phase separation (LLPS) of biomolecules is a phenomenon which is nowadays recognized as the driving force for the biogenesis of numerous functional membraneless organelles and cellular bodies. The interplay between the protein primary sequence and phase separation remains poorly understood, despite intensive research. To uncover the sequence-encoded signals of protein capable of undergoing LLPS, we developed a novel web platform named BIAPSS (Bioinformatics Analysis of LLPS Sequences). This web server provides on-the-fly analysis, visualization, and interpretation of the physicochemical and structural features for the superset of curated LLPS proteins.

Indexed as

Intrinsically Disordered ProteinsOrganellesIntrinsically Disordered Proteinsintrinsically disordered proteinsliquid–liquid phase separationmembraneless organellesproteins with low complexity

Identifiers

PMID35682883
PMCPMC9181037
OpenAlexW4281765256

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.