Evidence map›Paper›PMID 35682836›Full record

ArticleInternational journal of molecular sciences2022

Butylidenephthalide Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas.

Pei-Yin Chen, Shih-Chi Chao, Pei-Ling Hsieh, Yi-Wen Liao, Pei-Ming Chu, Horng-Jyh Harn, Cheng-Chia Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. A Systematic Evaluation ofFoods (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Pei-Yin ChenSchool of Dentistry, Chung Shan Medical University, Taichung 402, Taiwan.
Shih-Chi ChaoInstitute of Oral Sciences, Chung Shan Medical University, Taichung 402, Taiwan.ORCID 0000-0002-0920-9340
Pei-Ling HsiehDepartment of Anatomy, School of Medicine, China Medical University, Taichung 404, Taiwan.
Yi-Wen LiaoDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Pei-Ming ChuDepartment of Anatomy, School of Medicine, China Medical University, Taichung 404, Taiwan.
Horng-Jyh HarnBuddhist Tzu Chi Bioinnovation Center, Tzu Chi Foundation, Hualien 970, Taiwan.
Cheng-Chia YuSchool of Dentistry, Chung Shan Medical University, Taichung 402, Taiwan.
Chung Shan Medical University Hospital · TWChina Medical University · TWLuodong Poh-Ai Hospital · TWTzu Chi University · TW

Funding

Chung Shan Medical University Hospital CSH-2022-C-008
6 · The paper itself

Abstract

Oral cancer is one of the most common cancers worldwide, especially in South Central Asia. It has been suggested that cancer stem cells (CSC) play crucial roles in tumor relapse and metastasis, and approaches to target CSC may lead to promising results. Here, aldehyde dehydrogenase 1 (ALDH1) and CD44 were utilized to isolate CSCs of oral cancer. Butylidenephthalide, a bioactive phthalide compound from

Indexed as

CarcinomaMouth NeoplasmsAldehyde Dehydrogenase 1 FamilyAnimalsCell Line, TumorHumansHyaluronan ReceptorsIsoenzymesMiceNeoplasm Recurrence, LocalNeoplastic Stem CellsPhthalic AnhydridesRetinal DehydrogenaseSnail Family Transcription FactorsAldehyde Dehydrogenase 1 FamilybutylidenephthalideHyaluronan ReceptorsIsoenzymesPhthalic AnhydridesRetinal DehydrogenaseSNAI1 protein, humanSnail Family Transcription FactorsALDH1butylidenephthalidecancer stem cellsCD44oral cancerSnail

Identifiers

PMID35682836
PMCPMC9180956
OpenAlexW4281652045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.