ReviewInternational journal of molecular sciences2022
Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications-A Narrative Review.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Effects of exercise on clinical outcomes in patients undergoing haemodialysis for chronic kidney disease: an umbrella review.Journal of global health · 2026Pooled it
- Whole body resistance training on functional outcomes of patients with Stage 4 or 5 chronic kidney disease: A systematic review.Physiological reports · 2024Pooled it
- Organokines in COVID-19: A Systematic Review.Cells · 2023Pooled it
- Intradialytic neuromuscular electrical stimulation improves muscle oxygenation and aerobic capacity in end-stage renal disease: a single-blind, randomized controlled trial.Scientific reports · 2026Trial
- The Combined Use of Hydroxymethylbutyrate and Branched-Chain Amino Acids to Counteract Uremic Sarcopenia.Nutrients · 2026Trial
- Trial
- Article
- Effects of neuromuscular electrical stimulation (NMES) in patients undergoing haemodialysis: a systematic review and meta-analysis.International urology and nephrology · 2026Review
- Article
- Effects of Parathyroidectomy on Muscle Mass, Strength, and Physical Function in Uremia-Associated Secondary Hyperparathyroidism.Healthcare (Basel, Switzerland) · 2026Article
- Total Body Muscle Mass in Heart Failure: A Marker of Muscle Loss or Systemic Vulnerability?Geriatrics & gerontology international · 2026Article
- Adverse Muscle Composition Is Associated with All-Cause Mortality in CKD: A UK Biobank Imaging Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Renal function-improving action of Pentadecyl®, a multifunctional triglyceride fromExperimental and therapeutic medicine · 2026Article
- Interpretable machine learning model for predicting hemorrhage following ultrasound-guided percutaneous renal biopsy: a multicenter study.Abdominal radiology (New York) · 2026Article
- Exercise-induced modulation of the unfolded protein response: a therapeutic avenue for muscle wasting disorders.Journal of physiology and biochemistry · 2026Review
- Body composition paradox: high muscle mass and adiposity jointly predict incident chronic kidney disease in a Korean cohort.Clinics (Sao Paulo, Brazil) · 2026Article
- Association Between Physical Activity Levels and Mortality and Cardiovascular Disease in Chronic Kidney Disease: A Protocol for a Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Article
- Assessing Functional Cognition in People on Maintenance Hemodialysis Using Performance-Based Testing.Kidney360 · 2026Article
- Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?Aging cell · 2026Review
- Bidirectional association between sarcopenia and diabetic kidney disease: a prospective cohort study.BMC nephrology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In this narrative review, we discuss the cardinal role of the insulin-like growth factor 1 and myostatin signaling pathways, which have been extensively investigated using animal and human studies, as well as the emerging concepts in microRNA- and gut microbiota-mediated regulation of muscle mass and myogenesis. To ameliorate muscle loss, therapeutic strategies, including nutritional support, exercise programs, pharmacological interventions, and physical modalities, are being increasingly developed based on advances in understanding its underlying pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.