Evidence map›Paper›PMID 35682679›Full record

ArticleInternational journal of molecular sciences2022

Progression and Dissemination of Pulmonary Mycobacterium Avium Infection in a Susceptible Immunocompetent Mouse Model.

Raymond Rosenbloom, Igor Gavrish, Anna E Tseng, Kerstin Seidel, Shivraj M Yabaji, Hans P Gertje, Bertrand R Huber, Igor Kramnik, Nicholas A Crossland

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Strain-specific persistence ofJournal of medical microbiology · 2026
    Article
  2. Article
  3. Article
  4. C3HeB/FeJ mice with chronicMycobacteria (London, England) · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. The Many Hosts of Mycobacteria 9 (MHM9): A conference report.Tuberculosis (Edinburgh, Scotland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Raymond RosenbloomGraduate Medical Sciences, Boston University School of Medicine, Boston, MA 02118, USA.
Igor GavrishNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.
Anna E TsengNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.
Kerstin SeidelNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.
Shivraj M YabajiNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-5793-1661
Hans P GertjeNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.
Bertrand R HuberDepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
Igor KramnikNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.ORCID 0000-0001-6511-9246
Nicholas A CrosslandNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.ORCID 0000-0003-3873-9188
Boston University · US

Funding

Necrosis in pulmonary TB granulomas: dynamics, mechanisms, therapiesR01HL126066 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KRAMNIK, IGOR, NIEDERWEIS, MICHAEL · 2016 to 2025
$5.6M
Aberrant immune activation in the tuberculosis granuloma: a pivotal role in necrosisR01HL133190 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BISHAI, WILLIAM RAMSES, KRAMNIK, IGOR · 2016 to 2019
$3.0M
Vectra Polaris Quantitative Pathology Imaging SystemS10OD030269 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2021 to 2021
$402k
Ventana Discovery Ultra Research Autostainer: an Ex+ Core serviceS10OD026983 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2019 to 2019
$207k
NHLBI NIH HHS R01 HL126066NHLBI NIH HHS R01 HL133190NIH HHS R01 HL126066NIH HHS R01 HL133190NIH HHS S10 OD026983NIH HHS S10OD026983NIH HHS S10 OD030269NIH HHS S10OD030269
6 · The paper itself

Abstract

Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM), Mycobacterium avium complex (MAC), are a growing public health concern with incidence and mortality steadily increasing globally. Granulomatous inflammation is the hallmark of MAC lung infection, yet reliable correlates of disease progression, susceptibility, and resolution are poorly defined. Unlike widely used inbred mouse strains, mice that carry the mutant allele at the genetic locus sst1 develop human-like pulmonary tuberculosis featuring well-organized caseating granulomas. We characterized pulmonary temporospatial outcomes of intranasal and left intrabronchial

Indexed as

Mycobacterium avium-intracellulare InfectionPneumoniaAnimalsDisease Models, AnimalDisease ProgressionDisease SusceptibilityGranulomaMiceMice, Inbred StrainsMycobacterium aviumMycobacterium avium Complexdigital image analysisgranulomatous pneumoniahistopathologymacrophage polarizationnontuberculosis mycobacteria

Identifiers

PMID35682679
PMCPMC9181083
OpenAlexW4281718582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.