Evidence map›Paper›PMID 35682670›Full record

ArticleInternational journal of molecular sciences2022

Synergistic Effects of A Combined Treatment of Glioblastoma U251 Cells with An Anti-miR-10b-5p Molecule and An AntiCancer Agent Based on 1-(3',4',5'-Trimethoxyphenyl)-2-Aryl-1

Matteo Zurlo, Romeo Romagnoli, Paola Oliva, Jessica Gasparello, Alessia Finotti, Roberto Gambari

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matteo ZurloDepartment of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.ORCID 0000-0002-6131-3727
Romeo RomagnoliDepartment of Chemical, Pharmaceutical and Agricultural Sciences, Ferrara University, 44121 Ferrara, Italy.ORCID 0000-0002-6374-773X
Paola OlivaDepartment of Chemical, Pharmaceutical and Agricultural Sciences, Ferrara University, 44121 Ferrara, Italy.ORCID 0000-0002-9148-931X
Jessica GasparelloDepartment of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.ORCID 0000-0001-8557-0739
Alessia FinottiDepartment of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.ORCID 0000-0002-7638-515X
Roberto GambariDepartment of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.ORCID 0000-0001-9205-6033

Funding

European Union GA #633937Italian Association for Cancer Research IG #13575
6 · The paper itself

Abstract

(1) Background: In the development of new and more effective anticancer approaches, combined treatments appear of great interest. Combination therapy could be of importance in the management of glioblastoma (GBM), a lethal malignancy that accounts for 42% of cancer of the central nervous system, with a median survival of 15 months. This study aimed to verify the activity on a glioblastoma cancer cell line of one of the most active compounds of a novel series of tubulin polymerization inhibitors based on the 1-(3',4',5'-trimethoxyphenyl)-2-aryl-1

Indexed as

Antineoplastic AgentsBrain NeoplasmsGlioblastomaMicroRNAsAntagomirsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansImidazolesAntagomirsAntineoplastic AgentsImidazolesMicroRNAs1-(3′,4′,5′-trimethoxyphenyl)-2-aryl-1H-imidazoleanti-miRapoptosiscombination therapygliomamicroRNAmiR-10b-5ptubulin

Identifiers

PMID35682670
PMCPMC9181338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.