Evidence map›Paper›PMID 35682659›Full record

ArticleInternational journal of molecular sciences2022

Disruption of Redox Homeostasis by Alterations in Nitric Oxide Synthase Activity and Tetrahydrobiopterin along with Melanoma Progression.

Jaqueline Pereira Moura Soares, Diego Assis Gonçalves, Ricardo Xisto de Sousa, Margareth Gori Mouro, Elisa M S Higa, Letícia Paulino Sperandio, Carolina Moraes Vitoriano, Elisa Bachir Santa Rosa, Fernanda Oliveira Dos Santos, Gustavo Nery de Queiroz and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jaqueline Pereira Moura SoaresDepartment of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo 01224-001, Brazil.
Diego Assis GonçalvesDepartment of Parasitology, Microbiology and Immunology, Juiz de Fora Federal University, Juiz de Fora 36036-900, Brazil.ORCID 0000-0002-7351-3558
Ricardo Xisto de SousaDepartment of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo 01224-001, Brazil.
Margareth Gori MouroNefrology Discipline, Federal University of Sao Paulo, São Paulo 05508-090, Brazil.
Elisa M S HigaNefrology Discipline, Federal University of Sao Paulo, São Paulo 05508-090, Brazil.
Letícia Paulino SperandioDepartment of Pharmacology, Federal University of Sao Paulo, São Paulo 05508-090, Brazil.
Carolina Moraes VitorianoDepartment of Pharmacology, Institute of Biomedical Science, Universidade de São Paulo, São Paulo 05505-000, Brazil.
Elisa Bachir Santa RosaDepartment of Pharmacology, Institute of Biomedical Science, Universidade de São Paulo, São Paulo 05505-000, Brazil.
Fernanda Oliveira Dos SantosDepartment of Pharmacology, Institute of Biomedical Science, Universidade de São Paulo, São Paulo 05505-000, Brazil.
Gustavo Nery de QueirozDepartment of Pharmacology, Institute of Biomedical Science, Universidade de São Paulo, São Paulo 05505-000, Brazil.
Roberta Sessa Stilhano YamaguchiDepartment of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo 01224-001, Brazil.
Gustavo PereiraDepartment of Pharmacology, Federal University of Sao Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0002-6765-1276
Marcelo Yudi IcimotoBiophysics Department, Federal University of Sao Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0002-0746-5279
Fabiana Henriques Machado de MeloDepartment of Pharmacology, Institute of Biomedical Science, Universidade de São Paulo, São Paulo 05505-000, Brazil.

Funding

Fundação de Apoio à Pesquisa do Estado de São Paulo 2017/04352-0; 2017/10695-7; 2021/12988-7; 2021/12988-7
6 · The paper itself

Abstract

Cutaneous melanoma emerges from the malignant transformation of melanocytes and is the most aggressive type of skin cancer. The progression can occur in different stages: radial growth phase (RGP), vertical growth phase (VGP), and metastasis. Reactive oxygen species contribute to all phases of melanomagenesis through the modulation of oncogenic signaling pathways. Tetrahydrobiopterin (BH4) is an important cofactor for NOS coupling, and an uncoupled enzyme is a source of superoxide anion (O

Indexed as

MelanomaSkin NeoplasmsBiopterinsHomeostasisHumansNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIIOxidation-ReductionPhosphatidylinositol 3-KinasesBiopterinsNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIIPhosphatidylinositol 3-Kinasessapropterinmelanomanitric oxidenitric oxide synthasereactive oxygen speciesredox homeostasistetrahydrobiopterin

Identifiers

PMID35682659
PMCPMC9181279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.