Evidence map›Paper›PMID 35682653›Full record

ArticleInternational journal of molecular sciences2022

Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis.

Ling-Hui Chu, Chi-Chun Liao, Phui-Ly Liew, Chien-Wen Chen, Po-Hsuan Su, Kuo-Chang Wen, Hung-Cheng Lai, Rui-Lan Huang, Lin-Yu Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ling-Hui ChuDepartment of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Chi-Chun LiaoDepartment of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Phui-Ly LiewDepartment of Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Chien-Wen ChenDr Wang Reproductive Fertility Center, Taipei 110007, Taiwan.
Po-Hsuan SuDepartment of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.ORCID 0000-0003-1114-6382
Kuo-Chang WenDepartment of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Hung-Cheng LaiDepartment of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Rui-Lan HuangDepartment of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Lin-Yu ChenDepartment of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.ORCID 0000-0003-4870-3664
Taipei Medical University-Shuang Ho Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST108-2314-B-038-096Ministry of Science and Technology, Taiwan MOST 109-2314-B-038-052-MY3Ministry of Science and Technology, Taiwan MOST 109-2314-B-038-107-MY3Ministry of Science and Technology, Taiwan MOST110-2314-B-038-058Ministry of Science and Technology, Taiwan MOST 110-2314-B-038-060Ministry of Science and Technology, Taiwan MOST 110WFD2010656National Health Research Institutes, Taiwan NHRI-EX106-10406BITaipei Medical University-Shuang Ho Hospital, Taiwan 109TMU-SHH-20 to LYC
6 · The paper itself

Abstract

Adenomyosis is linked to dysmenorrhea and infertility. The pathogenesis of adenomyosis remains unclear, and little is known of the genetic and epigenetic changes in the eutopic endometrium in adenomyosis, which may predispose patients to the invasion and migration of endometrial tissues into the myometrium. Transcriptome studies have identified genes related to various cell behaviors but no targets for therapeutic intervention. The epigenetics of the eutopic endometrium in adenomyosis have rarely been investigated. Endometrial tissue was obtained from premenopausal women with (

Indexed as

AdenomyosisEndometriosisInfertilityPotassium Channels, Tandem Pore DomainDysmenorrheaEndometriumEpigenomicsFemaleHumansPotassium ChannelsKCNK9 protein, humanPotassium ChannelsPotassium Channels, Tandem Pore DomainadenomyosisepigenomicsKCNK9methylationpotassium channel

Identifiers

PMID35682653
PMCPMC9180761
OpenAlexW4281562285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.