Evidence map›Paper›PMID 35682566›Full record

ArticleInternational journal of molecular sciences2022

Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.

Redona Hafizi, Faik Imeri, Bisera Stepanovska Tanturovska, Roxana Manaila, Stephanie Schwalm, Sandra Trautmann, Roland H Wenger, Josef Pfeilschifter, Andrea Huwiler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Sphingolipid signaling in kidney diseases.American journal of physiology. Renal physiology · 2025
    Review
  2. Review
  3. Role of Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Redona HafiziInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.
Faik ImeriInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.
Bisera Stepanovska TanturovskaInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.
Roxana ManailaInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.
Stephanie SchwalmInstitute of General Pharmacology and Toxicology, University Hospital Frankfurt am Main, Goethe-University, Theodor-Stern Kai 7, D-60590 Frankfurt am Main, Germany.
Sandra TrautmannInstitute of Clinical Pharmacology, University Hospital Frankfurt am Main, Goethe-University, Theodor-Stern Kai 7, D-60590 Frankfurt am Main, Germany.
Roland H WengerInstitute of Physiology, University of Zürich, CH-8057 Zürich, Switzerland.ORCID 0000-0001-7592-4839
Josef PfeilschifterInstitute of General Pharmacology and Toxicology, University Hospital Frankfurt am Main, Goethe-University, Theodor-Stern Kai 7, D-60590 Frankfurt am Main, Germany.
Andrea HuwilerInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.ORCID 0000-0003-1615-5691
University of Bern · CHGoethe University Frankfurt · DEUniversity of Zurich · CH

Funding

Deutsche Forschungsgemeinschaft SFB1039Hochschulstiftung der Universität Bern 20/2020Swiss National Science Foundation 310030_175561/1 and 310030_184813
6 · The paper itself

Abstract

Erythropoietin (Epo) is a crucial hormone regulating red blood cell number and consequently the hematocrit. Epo is mainly produced in the kidney by interstitial fibroblast-like cells. Previously, we have shown that in cultures of the immortalized mouse renal fibroblast-like cell line FAIK F3-5, sphingosine 1-phosphate (S1P), by activating S1P

Indexed as

ErythropoietinSphingosineAnimalsBasic Helix-Loop-Helix ProteinsEpoetin AlfaFibroblastsHypoxiaKidneyMicePhosphotransferases (Alcohol Group Acceptor)RNA, MessengerSphingosine KinaseBasic Helix-Loop-Helix ProteinsEpoetin AlfaErythropoietinPhosphotransferases (Alcohol Group Acceptor)RNA, MessengerSphingosineSphingosine Kinasesphingosine kinase 2, mouseSphk1 protein, mouseanemiaHIF-2α, erythropoietinrenal fibroblastssphingosinesphingosine 1-phosphateSphk1Sphk2

Identifiers

PMID35682566
PMCPMC9180811
OpenAlexW4281563672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.