Evidence map›Paper›PMID 35682548›Full record

ArticleInternational journal of molecular sciences2022

Intermittent Hypoxia Increased the Expression of DBH and PNMT in Neuroblastoma Cells via MicroRNA-375-Mediated Mechanism.

Shin Takasawa, Ryogo Shobatake, Yoshinori Takeda, Tomoko Uchiyama, Akiyo Yamauchi, Mai Makino, Sumiyo Sakuramoto-Tsuchida, Keito Asai, Hiroyo Ota, Asako Itaya-Hironaka

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. The Impact of Intermittent Hypoxia on Metabolism and Cognition.International journal of molecular sciences · 2022
    Review
  10. Upregulation ofInternational journal of molecular sciences · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shin TakasawaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.ORCID 0000-0002-4066-0199
Ryogo ShobatakeDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.ORCID 0000-0002-4165-1200
Yoshinori TakedaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.ORCID 0000-0001-7738-5576
Tomoko UchiyamaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Akiyo YamauchiDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.ORCID 0000-0001-9417-4738
Mai MakinoDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Sumiyo Sakuramoto-TsuchidaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Keito AsaiDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Hiroyo OtaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.
Asako Itaya-HironakaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Nara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep apnea syndrome (SAS), characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia (IH)), is a risk factor for hypertension and insulin resistance. We report a correlation between IH and insulin resistance/diabetes. However, the reason why hypertension is induced by IH is elusive. Here, we investigated the effect of IH on the expression of catecholamine-metabolizing enzymes using an in vitro IH system. Human and mouse neuroblastoma cells (NB-1 and Neuro-2a) were exposed to IH or normoxia for 24 h. Real-time RT-PCR revealed that IH significantly increased the mRNA levels of

Indexed as

HypertensionInsulin ResistanceMicroRNAsNeuroblastomaAnimalsDopamine beta-HydroxylaseHumansHypoxiaMicePhenylethanolamine N-MethyltransferaseTyrosine 3-MonooxygenaseDopamine beta-HydroxylaseMicroRNAsMIRN375 microRNA, humanPhenylethanolamine N-MethyltransferaseTyrosine 3-Monooxygenasecatecholaminesdopamine β-hydroxylasehypertensionintermittent hypoxiamiR-375neuroblastoma cellsphenylethanolamine N-methyltransferasesleep apnea syndrome

Identifiers

PMID35682548
PMCPMC9180443

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.