Evidence map›Paper›PMID 35681671›Full record

ArticleCancers2022

Addition of Standard Enzalutamide Medication Shows Synergistic Effects on Response to [

Florian Rosar, Hanna Bader, Mark Bartholomä, Stephan Maus, Caroline Burgard, Johannes Linxweiler, Fadi Khreish, Samer Ezziddin

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Targeted Radionuclide Therapy: Current Landscape and Combination Approaches to Improve Oncology Outcomes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  2. Effects of androgen receptor signaling inhibitors on absorbed doses in mCRPC patients undergoing [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Article
  5. Comparison of mCRPC [European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Article
  7. Efficacy and safety of rechallenge [European journal of nuclear medicine and molecular imaging · 2024
    Observational
  8. Change in total lesion PSMA (TLP) during [European journal of nuclear medicine and molecular imaging · 2024
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Florian RosarDepartment of Nuclear Medicine, Saarland University Hospital, 66421 Homburg, Germany.ORCID 0000-0002-2985-4099
Hanna BaderDepartment of Nuclear Medicine, Saarland University Hospital, 66421 Homburg, Germany.
Mark BartholomäDepartment of Nuclear Medicine, Saarland University Hospital, 66421 Homburg, Germany.ORCID 0000-0002-0361-2833
Stephan MausDepartment of Nuclear Medicine, Saarland University Hospital, 66421 Homburg, Germany.
Caroline BurgardDepartment of Nuclear Medicine, Saarland University Hospital, 66421 Homburg, Germany.ORCID 0000-0003-1522-8860
Johannes LinxweilerDepartment of Urology, Saarland University Hospital, 66421 Homburg, Germany.
Fadi KhreishDepartment of Nuclear Medicine, Saarland University Hospital, 66421 Homburg, Germany.ORCID 0000-0002-1036-7477
Samer EzziddinDepartment of Nuclear Medicine, Saarland University Hospital, 66421 Homburg, Germany.ORCID 0000-0003-4110-3375
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Well-received strong efficacy of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) does not prevent patients from either early or eventual disease progression under this treatment. In this study, we investigated co-medication with enzalutamide as a potential re-sensitizer for PSMA-RLT in patients with imminent treatment failure on standard

Indexed as

enzalutamidemCRPCPSMAradioligand therapyradiosensitizerupregulation

Identifiers

PMID35681671
PMCPMC9179420
OpenAlexW4281670341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.