Evidence map›Paper›PMID 35681602›Full record

ArticleCancers2022

Pilot Investigation on p75ICD Expression in Laryngeal Squamous Cell Carcinoma.

Viviana Triaca, Elena Fico, Pamela Rosso, Massimo Ralli, Alessandro Corsi, Cinzia Severini, Alvaro Crevenna, Enzo Agostinelli, Emma Rullo, Mara Riminucci and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Viviana TriacaInstitute of Biochemistry and Cell Biology, National Research Council (CNR), International Campus A. Buzzati-Traverso, Monterotondo Scalo, 00015 Rome, Italy.ORCID 0000-0001-8290-7279
Elena FicoDepartment of Sense Organs, Institute of Biochemistry and Cell Biology, National Research Council (CNR), University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0003-1730-277X
Pamela RossoDepartment of Sense Organs, Institute of Biochemistry and Cell Biology, National Research Council (CNR), University of Rome La Sapienza, 00185 Rome, Italy.
Massimo RalliDepartment of Sense Organs, University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0001-8776-0421
Alessandro CorsiDepartment of Molecular Medicine, University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0001-6896-4509
Cinzia SeveriniDepartment of Sense Organs, Institute of Biochemistry and Cell Biology, National Research Council (CNR), University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0002-6932-704X
Alvaro CrevennaEpigenetics and Neurobiology Unit, EMBL Rome, International Campus A. Buzzati-Traverso, Monterotondo Scalo, 00015 Rome, Italy.ORCID 0000-0002-5580-3711
Enzo AgostinelliDepartment of Sense Organs, University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0002-2508-8868
Emma RulloDepartment of Molecular Medicine, University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0003-4152-5025
Mara RiminucciDepartment of Molecular Medicine, University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0002-8643-9211
Andrea ColizzaDepartment of Sense Organs, University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0002-0639-806X
Antonella PolimeniDepartment of Oral and Maxillo Facial Sciences, University of Rome La Sapienza, 00185 Rome, Italy.ORCID 0000-0002-2679-7607
Antonio GrecoDepartment of Sense Organs, University of Rome La Sapienza, 00185 Rome, Italy.
Paola TirassaDepartment of Sense Organs, Institute of Biochemistry and Cell Biology, National Research Council (CNR), University of Rome La Sapienza, 00185 Rome, Italy.
Sapienza University of Rome · ITNational Research Council · ITEuropean Molecular Biology Laboratory · IT

Funding

Sapienza University of Rome GrandiProgetti 2019
6 · The paper itself

Abstract

We investigated the p75 Neurotrophin Receptor (p75NTR) expression and cleavage product p75NTR Intracellular Domain (p75ICD) as potential oncogenic and metastatic markers in human Laryngeal Squamous Cell Carcinoma (LSCC). p75NTR is highly expressed in Cancer Stem Cells (CSCs) of the laryngeal epithelia and it has been proposed as a marker for stemness, cell migration, and chemo-resistance in different squamous carcinomas. To investigate the clinical significance of p75NTR cleavage products in solid tumors, full-length and cleaved p75NTR expression was analyzed in laryngeal primary tumors from different-stage LSCC patients, diagnosed at the Policlinico Umberto I Hospital. Molecular and histological techniques were used to detect the expressions of p75NTR and p75ICD, and ATP Binding Cassette Subfamily G Member 2 (ABCG2), a CSC marker. We found regulated p75NTR cleavage during squamous epithelial tumor progression and tissue invasion. Our preliminary investigation suggests p75ICD expression and localization as possible features of tumorigenesis and metastaticity. Its co-localization with ABCG2 in squamous cells in the parenchyma invaded by the tumor formation allows us to hypothesize p75NTR and p75ICD roles in tumor invasion and CSC spreading in LSCC patients. These data might represent a starting point for a comprehensive analysis of p75NTR cleavage and of its clinical relevance as a potential molecular LSCC signature, possibly helping diagnosis, and improving prognosis and personalized therapy.

Indexed as

ABCG2CSCsLSCCp75ICDp75NTRtumor invasion

Identifiers

PMID35681602
PMCPMC9179539
OpenAlexW4281558085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.