Evidence map›Paper›PMID 35681537›Full record

ArticleCells2022

Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia.

Yi Gong, Fiza Laheji, Anna Berenson, April Qian, Sang-O Park, Rene Kok, Martin Selig, Ryan Hahn, Reza Sadjadi, Stephan Kemp and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yi GongDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Fiza LahejiDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Anna BerensonDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
April QianDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Sang-O ParkDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Rene KokLaboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Amsterdam University Medical Center, Amsterdam Gastroenterology Endocrinology Metabolism, University of Amsterdam, 1105 Amsterdam, The Netherlands.
Martin SeligDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ryan HahnDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-3482-8247
Reza SadjadiDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Stephan KempLaboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Amsterdam University Medical Center, Amsterdam Gastroenterology Endocrinology Metabolism, University of Amsterdam, 1105 Amsterdam, The Netherlands.ORCID 0000-0003-2023-064X
Florian EichlerDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Harvard University · USEmma Kinderziekenhuis · NLUniversity of Amsterdam · NL

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4M
The Role of Desoxysphingoid Bases in HSAN1R01NS072446 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI EICHLER, FLORIAN S · 2011 to 2015
$2.1M
Safety, Tolerability and Biological Activity of L-serine in HSAN1.R01NS082331 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI EICHLER, FLORIAN S · 2013 to 2016
$411k
A Zeiss LSM800 confocal microscope with AiryscanS10OD021577 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2016 to 2016
$374k
NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIH HHS S10 OD021577NINDS NIH HHS R01 NS072446NINDS NIH HHS R01 NS082331
6 · The paper itself

Abstract

Mutations in the peroxisomal half-transporter ABCD1 cause X-linked adrenoleukodystrophy, resulting in elevated very long-chain fatty acids (VLCFA), progressive neurodegeneration and an associated pain syndrome that is poorly understood. In the nervous system of mice, we found ABCD1 expression to be highest in dorsal root ganglia (DRG), with satellite glial cells (SGCs) displaying higher expression than neurons. We subsequently examined sensory behavior and DRG pathophysiology in mice deficient in ABCD1 compared to wild-type mice. Beginning at 8 months of age,

Indexed as

AdrenoleukodystrophyAnimalsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily D, Member 1Fatty AcidsHyperalgesiaIon ChannelsMicePainPeroxisomesAbcd1 protein, mouseATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily D, Member 1Fatty AcidsIon ChannelsPiezo2 protein, mouseadrenomyeloneuropathy (AMN)allodyniadorsal root ganglion (DRG)glial fibrillary acidic protein (GFAP)mechanical hypersensitivitypainperoxisomesPIEZO2RNA-seqsatellite glial cells (SGCs)X-linked adrenoleukodystrophy (X-ALD)

Identifiers

PMID35681537
PMCPMC9180358
OpenAlexW4281611097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.