Evidence map›Paper›PMID 35681427›Full record

ArticleCells2022

Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency.

Megan B Borror, Milena Girotti, Adwitiya Kar, Meghan K Cain, Xiaoli Gao, Vivian L MacKay, Brent Herron, Shylesh Bhaskaran, Sandra Becerra, Nathan Novy and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Megan B BorrorThe Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Milena GirottiThe Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Adwitiya KarThe Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Meghan K CainThe Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Xiaoli GaoDepartment of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Vivian L MacKayDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Brent HerronInstitute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.
Shylesh BhaskaranThe Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Sandra BecerraThe Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Nathan NovyDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Natascia VenturaIUF-Leibniz Research Institute for Environmental Medicine, 103045 Düsseldorf, Germany.ORCID 0000-0001-8718-4321
Thomas E JohnsonInstitute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.
Brian K KennedyDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Shane L ReaThe Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-3818-4557
The University of Texas Health Science Center at San Antonio · USUniversity of Colorado Boulder · USUniversity of Washington · USBuck Institute for Research on Aging · USLeibniz Institute of Environmental Medicine · DE

Funding

San Antonio Biomedical Education and ResearchK12GM111726 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LECHLEITER, JAMES D, OYAJOBI, BABATUNDE OLUKAYODE · 2015 to 2024
$7.6M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Maintaining Mitochondrial Health into Old AgeR01AG055820 · NIA · UNIVERSITY OF WASHINGTON · PI REA, SHANE L. · 2018 to 2022
$1.9M
A 'Mitochondria-nucleus-ribosome' Signaling Axis Controls Lifespan in Mit MutantsR21AG047561 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI REA, SHANE L. · 2014 to 2015
$390k
Modes of Energy Production and clk-1 Life ExtensionR21AG025207 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI REA, SHANE · 2006 to 2007
$318k
NIA NIH HHS R01 AG055820NIA NIH HHS R21 AG025207NIA NIH HHS R21 AG047561NIGMS NIH HHS K12 GM111726NIH HHS P40 OD010440
6 · The paper itself

Abstract

Diseases that affect the mitochondrial electron transport chain (ETC) often manifest as threshold effect disorders, meaning patients only become symptomatic once a certain level of ETC dysfunction is reached. Cells can invoke mechanisms to circumvent reaching their critical ETC threshold, but it is an ongoing challenge to identify such processes. In the nematode

Indexed as

Ataxia Telangiectasia Mutated ProteinsCaenorhabditis elegans ProteinsMitochondriaAnimalsCaenorhabditis elegansCell RespirationNuclear ProteinsNucleotidesAtaxia Telangiectasia Mutated ProteinsAtl-1 protein, C elegansatm-1 protein, C elegansCaenorhabditis elegans ProteinsNuclear ProteinsNucleotidesageingagingcheckpoint responseDDRDNA damage responseMAK-1MAK-2MAPKAPsMit mutantspolysome profilingretrograde response

Identifiers

PMID35681427
PMCPMC9179431
OpenAlexW4281563921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.