ArticleFoods (Basel, Switzerland)2022
Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (
Article in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Ethnomedicinal Uses, Phytochemistry and Bioactivities of Halophytes and Salt-Tolerant Plants with Potential Against Metabolic Syndrome: A Comprehensive Review.Marine drugs · 2026Review
- Protective Effects of Mesembryanthemum Crystallinum Extract Against Cadmium-Induced Reproductive Oxidative Stress: Experimental and Docking Evidence for a Sustainable Therapeutic Strategy.Biological trace element research · 2026Article
- Techniques for the determination of dipeptidyl peptidase IV and screening of its inhibitors.Journal of pharmaceutical analysis · 2026Review
- Development and Characterization ofLife (Basel, Switzerland) · 2026Article
- ValorizingInternational journal of food science · 2026Article
- Potential protective effects ofFrontiers in pharmacology · 2026Article
- From Mushrooms to Molecules: Exploring Depsidones inMolecules (Basel, Switzerland) · 2025Article
- Effect of Electrical Conductivity of Nutrient Solution and Light Spectra on the Main Phytochemical Content ofPlants (Basel, Switzerland) · 2025Article
- Review
- London Rocket (Molecules (Basel, Switzerland) · 2024Article
- Growth parameters, phytochemicals, and antitumor activity of wild and cultivated ice plants (Food science & nutrition · 2024Article
- Comprehensive Review ofBiomolecules · 2024Review
- LC-QTOF/MS-Based Profiling of the Phytochemicals in Ice Plant (Foods (Basel, Switzerland) · 2024Article
- Nutrients and phytochemical density inSaudi journal of biological sciences · 2024Article
- Identification of Polyphenols in Sea Fennel (Foods (Basel, Switzerland) · 2023Article
- Bioactivity-Guided Isolation and Antihypertensive Activity ofMedicina (Kaunas, Lithuania) · 2023Article
- Effects ofAnimals : an open access journal from MDPI · 2023Article
- Optimization of Nutrient-Rich Ice Plant (Foods (Basel, Switzerland) · 2023Article
- Soilless Cultivated Halophyte Plants: Volatile, Nutritional, Phytochemical, and Biological Differences.Antioxidants (Basel, Switzerland) · 2023Article
- A Culturomics-Based Bacterial Synthetic Community for Improving Resilience towards Arsenic and Heavy Metals in the Nutraceutical PlantInternational journal of molecular sciences · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
This study aims to determine the potential antioxidant, antihypertensive, hypoglycaemic and nootropic activity of a purified polyphenolic extract from the halophyte ice plant (Mesembryanthemum crystallinum). The ice plant extract showed good antioxidant activity measured by DPPH, ORAC, TEAC, FRAP and ferrous ion chelating activity. Moreover, the extract showed potent ACE, DPP-IV and PEP-inhibitory activity (90.5%, 98.6% and 73.1%, respectively, at a final concentration of 1 mg/mL). The extract was fractionated and the fraction with the highest content of total phenolic compounds showed the highest bioactivity, suggesting that polyphenols could be mainly responsible for the abovementioned activities. The tentative polyphenol identification by HPLC-ESI-QTOF-MS in this fraction revealed that flavones (>65%) are the major group, with apigenin (38%) predominating, followed by diosmin (17.7%) and luteolin (11.9%). They could presumably be the main elements responsible for the enzymatic inhibition activity. Additionally, 4-hydroxybenzoic acid, p-coumaric acid and a hydroxycinnamic acid derivative (2-O-(p-cumaroyl)-l-malic acid) were found in the extract. To our knowledge, this is the first time that some of these activities have been reported for halophyte extracts.
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Registered trials
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