Evidence map›Paper›PMID 35681251›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2022

Does race-ethnicity affect upper airway stimulation adherence and treatment outcome of obstructive sleep apnea?

Meena Khan, Andre Stone, Ryan J Soose, Samuel M Cohen, Javier Howard, Robson Capasso, Deeyar Itayem, M Boyd Gillespie, Reena Mehra, Eugene Chio and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Bilateral hypoglossal nerve stimulation for obstructive sleep apnea: a nonrandomized clinical trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Trial
  2. Article
  3. Adherence to unilateral hypoglossal nerve stimulation and changes in Epworth Sleepiness Scale scores.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  4. Article
  5. Review
  6. How we measure hypoglossal nerve stimulator outcome matters: titration vs single amplitude efficacy sleep studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Meena KhanDivision of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Andre StoneUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Ryan J SooseDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Samuel M CohenDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
Javier HowardDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
Robson CapassoDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
Deeyar ItayemDepartment of Otolaryngology Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.
M Boyd GillespieDepartment of Otolaryngology Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.
Reena MehraSleep Disorders Center, Neurologic Institute, Respiratory Institute, Heart and Vascular Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Eugene ChioDepartment of Otolaryngology Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Patrick J StrolloDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine and Veterans Administration Pittsburgh Health System, Pittsburgh, Pennsylvania.
Anna MenzlInspire Medical Systems, Golden Valley, Minnesota.
Adam KaplanInspire Medical Systems, Golden Valley, Minnesota.
Quan NiInspire Medical Systems, Golden Valley, Minnesota.

Funding

Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating CenterU01HL125177 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BECK, GERALD J, ERZURUM, SERPIL C. · 2014 to 2020
$20.0M
Impact of Low Flow Nocturnal Oxygen Therapy On Hospital Readmission/Mortalityin Patients with Heart Failure and Central Sleep Apneal (LOFT-HF)UH3HL140144 · NHLBI · OHIO STATE UNIVERSITY · PI ABRAHAM, WILLIAM TOBER · 2019 to 2020
$5.5M
NHLBI NIH HHS U01 HL125177NHLBI NIH HHS UH3 HL140144
6 · The paper itself

Abstract

STUDY

objectivesUntreated obstructive sleep apnea (OSA) is associated with excessive daytime sleepiness, decreased quality of life, and cardiovascular disease. Positive airway pressure is the first-line therapy for OSA; however, adherence is difficult. Upper airway stimulation is a Food and Drug Administration-approved treatment of OSA. The objective of this study was to evaluate for a difference in treatment efficacy and adherence of upper airway stimulation therapy for OSA between individuals who are White and non-White using data from the ADHERE registry.

methodsADHERE registry is a multicenter prospective study of real-world experience of upper airway stimulation for treatment of OSA in the United States and Europe. Propensity score matching was used to create a balanced dataset between the White and non-White groups.

resultsThere were 2,755 participants of the ADHERE registry: 27 were excluded due to not having a race identified, 125 participants identified as non-White, 2,603 identify as White, and 27 did not provide race information. Propensity score matching was used to select 110 participants, with 55 White and 55 non-White for the noninferiority analysis. We did not find a difference in adherence, treatment apnea-hypopnea index, changes in Epworth Sleepiness Scale score, or clinical global impression after intervention score between White and non-White individuals.

conclusionsOur study found that there was no statistically significant difference in adherence or efficacy with upper airway stimulation therapy between White and non-White individuals. However, the percent of non-White people implanted is low, which suggests a need to expand access to this therapy for non-White populations with OSA who cannot tolerate positive airway pressure therapy. CITATION: Khan M, Stone A, Soose RJ, et al. Does race-ethnicity affect upper airway stimulation adherence and treatment outcome of obstructive sleep apnea?

Indexed as

Quality of LifeSleep Apnea, ObstructiveContinuous Positive Airway PressureEthnicityHumansProspective StudiesTreatment Outcomeadherenceapnea-hypopnea indexEpworth Sleepiness Scalehealth care disparitieshypoglossal nerve stimulationobstructive sleep apneapositive airway therapyupper airway stimulation

Identifiers

PMID35681251
PMCPMC9435342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.