ArticleBMC cancer2022
Post-recurrence survival analysis in patients with oligo-recurrence after curative esophagectomy.
Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Association between Surgical Waiting Time and Postoperative Recurrence Risk in Clinical T1bN0M0 Thoracic Esophageal Squamous Cell Carcinoma: A Multicenter Retrospective Observational Study.Annals of surgical oncology · 2026Observational
- Survival benefit of local treatment for oligo-recurrence after esophageal cancer surgery.World journal of surgical oncology · 2026Article
- The relationship between the treatment course and prognosis of oligometastasis after esophageal squamous cell carcinoma resection.Surgery today · 2024Article
- Prognostic Relevance of Recurrent Sites of Gastric Cancer Treated With Curative Resection: A Single Center Retrospective Study.Journal of gastric cancer · 2024Article
- Review
- Survival outcomes of esophageal cancer patients with recurrence after curative treatments.BMC cancer · 2023Article
- Article
- Survival after Lung Metastasectomy from Esophageal Cancer: Results from a Multi-Institutional Database.Cancers · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrent esophageal cancer is associated with dismal prognosis. There is no consensus about the role of surgical treatments in patients with limited recurrences. This study aimed to evaluate the role of surgical resection in patients with resectable recurrences after curative esophagectomy and to identify their prognostic factors.
methodsWe retrospectively reviewed patients with recurrent esophageal cancer after curative esophagectomy between 2004 and 2017 and included those with oligo-recurrence that was amenable for surgical intent. The prognostic factors of overall survival (OS) and post-recurrence survival (PRS), as well as the survival impact of surgical resection, were analyzed.
resultsAmong 654 patients after curative esophagectomies reviewed, 284 (43.4%) had disease recurrences. The recurrences were found resectable in 63 (9.6%) patients, and 30 (4.6%) patients received surgery. The significant prognostic factors of PRS with poor outcome included mediastinum lymph node (LN) recurrence and pathologic T3 stage. In patients with and without surgical resection for recurrence cancer, the 3-year OS rates were 65.6 and 47.6% (p = 0.108), while the 3-year PRS rates were 42.9 and 23.5% (p = 0.100). In the subgroup analysis, surgery for resectable recurrence, compared with non-surgery, could achieve better PRS for patients without any comorbidities (hazard ratio 0.36, 95% CI: 0.14 to 0.94, p = 0.038).
conclusionsMediastinum LN recurrence or pathologic T3 was associated with worse OS and PRS in patients with oligo-recurrences after curative esophagectomies. No definite survival benefit was noted in patients undergoing surgery for resectable recurrence, except in those without comorbidities.
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