ArticleCommunications biology2022
Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A generalized scaling law reveals synchrony-driven reorganization of brain dynamics across human lifespan.PLoS computational biology · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Linking EEG markers of oscillopathy and default mode network dysfunction in Alzheimer's disease.Frontiers in human neuroscience · 2026Review
- Explore brain-inspired machine intelligence for connecting dots on graphs through holographic blueprint of oscillatory synchronization.Nature communications · 2025Article
- Local homeostasis preserves global neural dynamics compensating for structural loss during human lifespan aging.Communications biology · 2025Article
- Quantifying the diverse contributions of hierarchical muscle interactions to motor function.iScience · 2025Article
- The virtual multiple sclerosis patient.iScience · 2024Article
- Metastability indexes global changes in the dynamic working point of the brain following brain stimulation.Frontiers in neurorobotics · 2024Article
- Multi-modal and multi-model interrogation of large-scale functional brain networks.NeuroImage · 2023Article
- White-matter degradation and dynamical compensation support age-related functional alterations in human brain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Noise-modulated multistable synapses in a Wilson-Cowan-based model of plasticity.Frontiers in computational neuroscience · 2023Article
- When the inner clock fades: Interoceptive decline and consolidation of phase resetting in cortical rhythms by cardiac events underlie healthy lifespan aging.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
4 authors.
Funding
Abstract
We propose that the preservation of functional integration, estimated from measures of neural synchrony, is a key objective of neurocompensatory mechanisms associated with healthy human ageing. To support this proposal, we demonstrate how phase-locking at the peak alpha frequency in Magnetoencephalography recordings remains invariant over the lifespan in a large cohort of human participants, aged 18-88 years. Using empirically derived connection topologies from diffusion tensor imaging data, we create an in-silico model of whole-brain alpha dynamics. We show that enhancing inter-areal coupling can cancel the effect of increased axonal transmission delays associated with age-related degeneration of white matter tracts, albeit at slower network frequencies. By deriving analytical solutions for simplified connection topologies, we further establish the theoretical principles underlying compensatory network re-organization. Our findings suggest that frequency slowing with age- frequently observed in the alpha band in diverse populations- may be viewed as an epiphenomenon of the underlying compensatory mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.