ArticlePediatric research2022
Neurological implications of antenatal corticosteroids on late preterm and term infants: a scoping review.
Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants.BMJ (Clinical research ed.) · 2023Pooled it
- Antenatal Corticosteroids: Short-Term Gains, Long-Term Questions-A Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Impact of Antenatal Corticosteroids on Brain Function and Underlying Mechanisms in Preclinical Studies: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- Evolutionary Integration and Glucocorticoid Regulation of the Respiratory System: Structure, Function, and Homeostatic Adaptation.Medical sciences (Basel, Switzerland) · 2026Review
- Associations between antenatal corticosteroids and neonatal morbidities in a prospective cohort: role of course, timing, and gestational age.Frontiers in pediatrics · 2026Article
- Article
- Betamethasone latency period and neonatal hypoglycemia in term infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025Article
- Multiple Sclerosis Relapse Treatment During Pregnancy and Offspring Functional and Structural Neurodevelopment: A Cross-Sectional Study.Neurology · 2025Observational
- Neonatal outcome in late preterm twin gestation: impact of antenatal corticosteroids therapy before 34 weeks.BMC pregnancy and childbirth · 2025Article
- Respiratory distress syndrome is the poster child for neonatology.Pediatric research · 2025Article
- The influence of antenatal betamethasone timing on neonatal outcome in late preterm infants: a single-center cohort study.Archives of gynecology and obstetrics · 2025Article
- Long-term outcomes of antenatal corticosteroids for preterm birth: An overview of systematic reviews.PLOS global public health · 2025Article
- [Effects of antenatal corticosteroids on outcomes of very premature infants and neurodevelopment during infancy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- "To Give or Not to Give": Evolution of Recommendations on Administering Antenatal Corticosteroids in Late Preterm or Early Term.Journal of obstetrics and gynaecology of India · 2024Article
- Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis.Archives of gynecology and obstetrics · 2023Article
- The role of antenatal corticosteroids in twin pregnancy.Frontiers in pharmacology · 2023Review
- Legislative remedies to mitigate the national emergency in pediatric mental health.Pediatric research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to synthesize the body of knowledge on the association between ACS exposure for risk of preterm birth and brain development in infants ultimately born late preterm and term. Three databases and eight conference proceedings were systematically searched (1972-2021). Selection criteria included ACS administration for risk of preterm delivery, cohort of late preterm and term infants, and assessment of brain development. Data on study characteristics, ACS administration, and neurological outcomes were extracted and qualitatively synthesized according to themes. Neurological outcomes of the included studies (n = 27) were grouped into four themes. The most common adverse outcomes were reduced neonatal head circumference, structural cortical differences on MRI, increased prevalence of psychiatric problems, and increased risk of neurodevelopmental delays in ACS-exposed late preterm and term infants. Our scoping review demonstrated that ACS exposure for risk of preterm delivery may have important neurological implications in infants ultimately born late preterm and term. Given that the existing research is at serious risk for bias, further research that accounts for confounders such as preterm labor, maternal stress, and the number of ACS courses is needed to better establish the long-term neurological effects of ACS on late preterm and term infants. IMPACT: Due to the difficulty in predicting preterm birth, approximately 40% of fetuses exposed to antenatal corticosteroids (ACS) are born at term (≥37 weeks' gestation). This scoping review summarizes the knowledge on the association between ACS exposure for risk of preterm birth and brain development in late preterm and term infants. The majority of studies reported that ACS exposure was associated with adverse brain development outcomes across various domains, such as reduced neonatal head circumference, cortical differences on MRI, and increased prevalence of psychiatric problems and neurodevelopmental delays in late preterm and term infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.