ArticleNature communications2022
A single-cell transcriptomic atlas characterizes the silk-producing organ in the silkworm.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Targeting the circadian negative regulatorMaterials today. Bio · 2026Article
- Self-assembling proteins compose the chemically resistant shell biomaterial of planktonic tintinnid ciliates.Nature communications · 2026Article
- Bombyx mori Jun gene is involved in endoreplication of silk gland cells by regulating S-phase cell cycle genes.Journal of advanced research · 2026Article
- Pan-Transcriptome Analyses of Multiple Tissues and Growth Stages Create Expression Atlases for the SilkwormAnimals : an open access journal from MDPI · 2026Article
- Single-cell and spatial transcriptomics define 20E-driven developmental reprogramming in silkworm wing disc.Nature communications · 2026Article
- CRISPR-Mediated Silkworm: The Oncoming Agricultural Revolutions and a Rising Model Organism.Genes · 2026Review
- The Nutritional, ACE Inhibition, and Antioxidant Properties of Hydrolysate Powders Derived from Different Stages of Thai Silkworm (Foods (Basel, Switzerland) · 2025Article
- Article
- Probiotic Bacillus subtilis enhances silkworm (Bombyx mori) growth performance and silk production via modulating gut microbiota and amino acid metabolism.Animal microbiome · 2025Article
- Establishing single cell RNA transcriptomics: a brief guide.Frontiers in zoology · 2025Review
- Regionalization of gene expression and cell types in the silk gland of the pantry mothbioRxiv : the preprint server for biology · 2025Article
- Article
- Residue-Specific Incorporation of Noncanonical Amino Acids in Auxotrophic Hosts:Chemical reviews · 2025Review
- BmHR3 Is Essential for Silk Gland Development and Silk Protein Synthesis in Silkworms (Insects · 2025Article
- BmNPV interacts with super-enhancer regions of the host chromatin to hijack cellular transcription machinery.Nucleic acids research · 2025Article
- Omics in mini-livestock: a genomic perspective on the future of sustainable food systems.Frontiers in genetics · 2025Review
- Advances in single-cell transcriptomics in animal research.Journal of animal science and biotechnology · 2024Review
- Molecular organization of fibroin heavy chain and mechanism of fibre formation in Bombyx mori.Communications biology · 2024Article
- SilkMeta: a comprehensive platform for sharing and exploiting pan-genomic and multi-omic silkworm data.Nucleic acids research · 2024Article
- Review
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The silk gland of the domesticated silkworm Bombyx mori, is a remarkable organ that produces vast amounts of silk with exceptional properties. Little is known about which silk gland cells execute silk protein synthesis and its precise spatiotemporal control. Here, we use single-cell RNA sequencing to build a comprehensive cell atlas of the silkworm silk gland, consisting of 14,972 high-quality cells representing 10 distinct cell types, in three early developmental stages. We annotate all 10 cell types and determine their distributions in each region of the silk gland. Additionally, we decode the developmental trajectory and gene expression status of silk gland cells. Finally, we discover marker genes involved in the regulation of silk gland development and silk protein synthesis. Altogether, this work reveals the heterogeneity of silkworm silk gland cells and their gene expression dynamics, affording a deeper understanding of silk-producing organs at the single-cell level.
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