Evidence map›Paper›PMID 35680949›Full record

ArticleScientific reports2022

New free radical-initiated peptide sequencing (FRIPS) mass spectrometry reagent with high conjugation efficiency enabling single-step peptide sequencing.

Sang Tak Lee, Hyemi Park, Inae Jang, Choong Sik Lee, Bongjin Moon, Han Bin Oh

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Analytical applications of gas-phase ion chemistry enabled by mass spectrometry.Analytical methods : advancing methods and applications · 2026
    Review
  3. Ion Mobility-Assisted Free Radical-Initiated Peptide Sequencing.International journal of mass spectrometry · 2025
    Article
  4. Article
  5. Improved Performance of Positive-Ion Mode Free Radical-Initiated Peptide Sequencing withJournal of the American Society for Mass Spectrometry · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sang Tak LeeDepartment of Chemistry, Sogang University, Seoul, 04107, Korea.
Hyemi ParkDepartment of Chemistry, Sogang University, Seoul, 04107, Korea.
Inae JangDepartment of Chemistry, Sogang University, Seoul, 04107, Korea.
Choong Sik LeeDepartment of Chemistry, Sogang University, Seoul, 04107, Korea.
Bongjin MoonDepartment of Chemistry, Sogang University, Seoul, 04107, Korea. bjmoon@sogang.ac.kr.
Han Bin OhDepartment of Chemistry, Sogang University, Seoul, 04107, Korea. hanbinoh@sogang.ac.kr.
Sogang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A newly designed TEMPO-FRIPS reagent, 4-(2,2,6,6-tetramethylpiperidine-1-oxyl) methyl benzyl succinic acid N-hydroxysuccinimide ester or p-TEMPO-Bn-Sc-NHS, was synthesized to achieve single-step free radical-initiated peptide sequencing mass spectrometry (FRIPS MS) for a number of model peptides, including phosphopeptides. The p-TEMPO-Bn-Sc-NHS reagent was conjugated to target peptides, and the resulting peptides were subjected to collisional activation. The peptide backbone dissociation behaviors of the MS/MS and MS

Indexed as

Sequence Analysis, ProteinTandem Mass SpectrometryFree RadicalsIndicators and ReagentsIonsPhosphopeptidesFree RadicalsIndicators and ReagentsIonsPhosphopeptides

Identifiers

PMID35680949
PMCPMC9184593
OpenAlexW4281731053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.