Evidence map›Paper›PMID 35680919›Full record

ArticleNature communications2022

Efferocytosis requires periphagosomal Ca

Michael S Schappe, Marta E Stremska, Gregory W Busey, Taylor K Downs, Philip V Seegren, Suresh K Mendu, Zachary Flegal, Catherine A Doyle, Eric J Stipes, Bimal N Desai

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Reactive Oxygen Species-Mediated TRPM2 Activation Facilitates Phagocytosis of Macrophages to Reverse Profibrotic Phenotype.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  8. Engineering Efferocytosis for Bone Regeneration.Macromolecular bioscience · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Efferocytosis and Bone Dynamics.Current osteoporosis reports · 2024
    Review
  15. Article
  16. Article
  17. TRPM channels in health and disease.Nature reviews. Nephrology · 2024
    Review
  18. TRP Ion Channels in Immune Cells and Their Implications for Inflammation.International journal of molecular sciences · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Michael S SchappePharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.ORCID 0000-0001-9889-2155
Marta E StremskaPharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.
Gregory W BuseyPharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.ORCID 0000-0002-4589-682X
Taylor K DownsPharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.
Philip V SeegrenPharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.
Suresh K MenduPharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.
Zachary FlegalPharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.
Catherine A DoylePharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.ORCID 0000-0002-5415-2371
Eric J StipesPharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA.ORCID 0000-0001-7512-0531
Bimal N DesaiPharmacology Department, University of Virginia, Pinn Hall, 1340 Jefferson Park Avenue, Charlottesville, VA, 22908, USA. bdesai@virginia.edu.ORCID 0000-0002-3928-5854
University of Virginia · USCarter Center · USHarvard University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4M
TRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2M
TRPM7 at the Crossroads of Tissue Homeostasis and inflammationR01GM108989 · NIGMS · UNIVERSITY OF VIRGINIA · PI DESAI, BIMAL N. · 2016 to 2024
$3.3M
Mitochondrial Calcium Signaling in Cell Intrinsic ImmunityR01AI155808 · NIAID · UNIVERSITY OF VIRGINIA · PI DESAI, BIMAL N. · 2021 to 2025
$2.8M
NIAID NIH HHS R01 AI155808NIGMS NIH HHS R01 GM108989NIGMS NIH HHS T32 GM007055NIGMS NIH HHS T32 GM007267
6 · The paper itself

Abstract

Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is fundamental to developmental biology, organ physiology, and immunology. Macrophages use multiple mechanisms to detect and engulf apoptotic cells, but the signaling pathways that regulate the digestion of the apoptotic cell cargo, such as the dynamic Ca

Indexed as

Calcium SignalingPhagocytosisTRPM Cation ChannelsAnimalsMacrophagesMicePhagosomesTrpm7 protein, mouseTRPM Cation Channels

Identifiers

PMID35680919
PMCPMC9184625
OpenAlexW4281721773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.