Evidence map›Paper›PMID 35680915›Full record

ArticleNature communications2022

Malaria oocysts require circumsporozoite protein to evade mosquito immunity.

Feng Zhu, Hong Zheng, Suilin Chen, Kun Zhang, Xin Qin, Jingru Zhang, Taiping Liu, Yongling Fan, Liting Wang, Xiaoxu Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  8. Article
  9. Review
  10. Late sporogonic stages ofbioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Late sporogonic stages ofFrontiers in cellular and infection microbiology · 2024
    Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Feng Zhu *Department of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China.ORCID 0000-0003-4845-109X
Hong Zheng *Department of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China.ORCID 0000-0003-3725-4541
Suilin ChenDepartment of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China.ORCID 0000-0002-7665-1278
Kun ZhangDepartment of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China.ORCID 0000-0002-4213-1186
Xin QinDepartment of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China.ORCID 0000-0002-2643-7927
Jingru ZhangDepartment of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China.ORCID 0000-0003-0668-5672
Taiping LiuDepartment of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China.ORCID 0000-0003-2261-1155
Yongling FanDepartment of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China.ORCID 0000-0001-7475-1294
Liting WangBiomedical Analysis Center, Army Medical University (Third Military Medical University), Chongqing, 400037, China.ORCID 0000-0003-3340-7475
Xiaoxu LiKey Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing, 400038, China.ORCID 0000-0002-6838-6902
Jian ZhangDepartment of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China. zhangjian@tmmu.edu.cn.ORCID 0000-0002-1318-6372
Wenyue XuDepartment of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing, 400038, China. xuwenyue@tmmu.edu.cn.ORCID 0000-0003-3681-5052
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria parasites are less vulnerable to mosquito immune responses once ookinetes transform into oocysts, facilitating parasite development in the mosquito. However, the underlying mechanisms of oocyst resistance to mosquito defenses remain unclear. Here, we show that circumsporozoite protein (CSP) is required for rodent malaria oocysts to avoid mosquito defenses. Mosquito infection with CSP

Indexed as

CulicidaeMalariaAnimalsOocystsProtozoan ProteinsSporozoitesProtozoan Proteins

Identifiers

PMID35680915
PMCPMC9184642
OpenAlexW4281721903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.