Evidence map›Paper›PMID 35680900›Full record

ArticleNature communications2022

Structural Basis for pH-gating of the K

Toby S Turney, Vivian Li, Stephen G Brohawn

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Structural basis for proton inhibition of the two-pore domain KStructure (London, England : 1993) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Structure-Function Relationships of KAdvances in experimental medicine and biology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Structure of the human KNature structural & molecular biology · 2025
    Article
  15. Structure of the human TWIK-2 potassium channel and its inhibition by pimozide.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Toby S TurneyBiophysics Graduate Program, University of California Berkeley, Berkeley, CA, 94720, USA.
Vivian LiDepartment of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Stephen G BrohawnDepartment of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, 94720, USA. brohawn@berkeley.edu.ORCID 0000-0001-6768-3406
QB3 · US

Funding

New approaches to understanding biological force sensationDP2GM123496 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROHAWN, STEPHEN GRAF · 2016 to 2016
$2.4M
NIGMS NIH HHS DP2 GM123496
6 · The paper itself

Abstract

TWIK1 (K2P1.1, KCNK1) is a widely expressed pH-gated two-pore domain K

Indexed as

Ion Channel GatingProtonsHydrogen-Ion ConcentrationLipidsLipidsProtons

Identifiers

PMID35680900
PMCPMC9184524
OpenAlexW4281687417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.