Evidence map›Paper›PMID 35680755›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023

Deep-learning-based methods of attenuation correction for SPECT and PET.

Xiongchao Chen, Chi Liu

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Beyond CT: Attenuation correction for stand-alone brain PET.Zeitschrift fur medizinische Physik · 2026
    Review
  2. Evolving SPECT-CT technology.The British journal of radiology · 2026
    Review
  3. Attenuation correction of cardiacEJNMMI physics · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. CT-free attenuation and Monte-Carlo based scatter correction-guided quantitativeEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  11. AI in SPECT Imaging: Opportunities and Challenges.Seminars in nuclear medicine · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xiongchao ChenDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Chi LiuDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA. chi.liu@yale.edu.

Funding

Development of advanced cardiac SPECT imaging technologiesR01HL154345 · NHLBI · YALE UNIVERSITY · PI LIU, CHI, SINUSAS, ALBERT J · 2020 to 2023
$3.2M
NHLBI NIH HHS R01 HL154345
6 · The paper itself

Abstract

Attenuation correction (AC) is essential for quantitative analysis and clinical diagnosis of single-photon emission computed tomography (SPECT) and positron emission tomography (PET). In clinical practice, computed tomography (CT) is utilized to generate attenuation maps (μ-maps) for AC of hybrid SPECT/CT and PET/CT scanners. However, CT-based AC methods frequently produce artifacts due to CT artifacts and misregistration of SPECT-CT and PET-CT scans. Segmentation-based AC methods using magnetic resonance imaging (MRI) for PET/MRI scanners are inaccurate and complicated since MRI does not contain direct information of photon attenuation. Computational AC methods for SPECT and PET estimate attenuation coefficients directly from raw emission data, but suffer from low accuracy, cross-talk artifacts, high computational complexity, and high noise level. The recently evolving deep-learning-based methods have shown promising results in AC of SPECT and PET, which can be generally divided into two categories: indirect and direct strategies. Indirect AC strategies apply neural networks to transform emission, transmission, or MR images into synthetic μ-maps or CT images which are then incorporated into AC reconstruction. Direct AC strategies skip the intermediate steps of generating μ-maps or CT images and predict AC SPECT or PET images from non-attenuation-correction (NAC) SPECT or PET images directly. These deep-learning-based AC methods show comparable and even superior performance to non-deep-learning methods. In this article, we first discussed the principles and limitations of non-deep-learning AC methods, and then reviewed the status and prospects of deep-learning-based methods for AC of SPECT and PET.

Indexed as

Deep LearningPositron Emission Tomography Computed TomographyHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPositron-Emission TomographyTomography, Emission-Computed, Single-PhotonAttenuation correctiondeep learningPETSPECT

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.