Evidence map›Paper›PMID 35680552›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Advancing the Science of Vaccine Safety During the Coronavirus Disease 2019 (COVID-19) Pandemic and Beyond: Launching an International Network of Special Immunization Services.

Karina A Top, Robert T Chen, Ofer Levy, Al Ozonoff, Bruce Carleton, Nigel W Crawford, C Buddy Creech, Sonali Kochhar, Gregory A Poland, Kimberley Gutu and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 4 countries.

Karina A TopDepartments of Pediatrics and Community Health & Epidemiology, Dalhousie University and Canadian Center for Vaccinology, IWK Health, Halifax, Nova Scotia, Canada.ORCID 0000-0002-9981-368X
Robert T ChenBrighton Collaboration, A program of The Task Force for Global Health, Decatur, Georgia, USA.ORCID 0000-0002-3094-8367
Ofer LevyPrecision Vaccines Program, Boston Children's Hospital, Boston, Massachusetts, USA.
Al OzonoffPrecision Vaccines Program, Boston Children's Hospital, Boston, Massachusetts, USA.
Bruce CarletonBC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Nigel W CrawfordRoyal Children's Hospital, Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
C Buddy CreechVanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sonali KochharGlobal Healthcare Consulting, New Delhi, India.
Gregory A PolandMayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA.
Kimberley GutuVaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Clare L CutlandAfrican Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Boston Children's Hospital · USUniversity of the Witwatersrand · ZADalhousie University · CAMayo Clinic in Florida · USRoyal Children's Hospital · AUThe Task Force for Global Health · USUniversity of British Columbia · CAUniversity of Washington · USVanderbilt University Medical Center · US

Funding

Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7M
This project focuses on increasing the number of local public health agencies across the stateH23IP000942 · IP · MISSOURI STATE DEPT/ HEALTH & SENIOR SRV · PI SULLIVAN, CATHY · 2014 to 2014
$500k
NCIRD CDC HHS H23 IP000942NIAID NIH HHS U19 AI118608
6 · The paper itself

Abstract

Within 2 years after the start of the coronavirus disease 2019 (COVID-19) pandemic, novel severe acute respiratory syndrome coronavirus 2 vaccines were developed, rigorously evaluated in large phase 3 trials, and administered to more than 5 billion individuals globally. However, adverse events of special interest (AESIs) have been described post-implementation, including myocarditis after receipt of messenger RNA (mRNA) vaccines and thrombosis with thrombocytopenia syndrome after receipt of adenoviral vector vaccines. AESIs are rare (<1 to 10/100 000 vaccinees) and less frequent than COVID-19 complications, though they have associated morbidity and mortality. The diversity of COVID-19 vaccine platforms (eg, mRNA, viral vector, protein) and rates of AESIs both between and within platforms (eg, higher rate of myocarditis after mRNA-1273 vs BNT162b2 vaccines) present an important opportunity to advance vaccine safety science. The International Network of Special Immunization Services has been formed with experts in vaccine safety, systems biology, and other relevant disciplines to study cases of AESIs and matched controls to uncover the pathogenesis of rare AESIs and inform vaccine development.

Indexed as

COVID-19MyocarditisBNT162 VaccineCOVID-19 VaccinesHumansImmunizationPandemicsRNA, MessengerBNT162 VaccineCOVID-19 VaccinesRNA, Messengeradverse events following immunizationgenomicssystems biologyvaccination

Identifiers

PMID35680552
PMCPMC9376276
OpenAlexW4281620986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.