Evidence map›Paper›PMID 35680418›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with

Gunnar Antoni, Mark Lubberink, Jens Sörensen, Elin Lindström, Mathias Elgland, Olof Eriksson, Michael Hultström, Robert Frithiof, Anders Wanhainen, Jonathan Sigfridsson and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Pulmonary embolism as an incidental finding in [European journal of nuclear medicine and molecular imaging · 2024
    Article
  7. Observational
  8. Total-Body Multiparametric PET Quantification ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  9. 2-deoxy-2-[Molecular imaging and biology · 2023
    Article
  10. Total-Body Multiparametric PET Quantification ofmedRxiv : the preprint server for health sciences · 2023
    Article
  11. PET Imaging of Neutrophil Elastase withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Gunnar AntoniDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden; gunnar.antoni@akademiska.se.
Mark LubberinkDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; and.
Jens SörensenDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; and.
Elin LindströmDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; and.
Mathias ElglandDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Olof ErikssonDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Michael HultströmDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; and.
Robert FrithiofDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; and.
Anders WanhainenDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; and.
Jonathan SigfridssonDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; and.
Paul SkorupDepartment of Medicinal Sciences, Uppsala University, Uppsala, Sweden.
Miklos LipcseyDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; and.
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) can cause life-threatening lung inflammation that is thought to be mediated by neutrophils. The aim of the present work was to evaluate a novel PET tracer for neutrophil elastase (NE).

Indexed as

COVID-19Lung DiseasesCarbon RadioisotopesHumansLeukocyte ElastaseLungNeutrophilsPositron-Emission TomographyCarbon RadioisotopesLeukocyte Elastase11C-GW457427neutrophil elastasePET

Identifiers

PMID35680418
PMCPMC9841261
OpenAlexW4282920329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.