Evidence map›Paper›PMID 35680080›Full record

SynthesisAgeing research reviews2022

Cortical excitability and plasticity in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis of transcranial magnetic stimulation studies.

Ying-Hui Chou, Mark Sundman, Viet Ton That, Jacob Green, Chrisopher Trapani

2 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Ageing research reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 13 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06207903 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Investigating Participation Behavior: An Observational Study in Mild Cognitive Impairment Clinical Trials

TypeobservationalSponsorPower Life Sciences Inc.Ran2025 to 2027Enrolled500ConditionsMild Cognitive Impairment
NCT07736092 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled130ConditionsOlder Adults, Surgery, Transcranial Photobiomodulation, Delayed Neurocognitive RecoveryArmsTranscranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 13 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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  14. Trial
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  16. Effects of accelerated intermittent theta-burst stimulation combined with cognitive training on brain function in amnestic mild cognitive impairment patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  18. Painless legs and moving toes phenotype in corticobasal syndrome with biomarker evidence of Alzheimer's disease: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ying-Hui ChouBrain Imaging and TMS Laboratory, Department of Psychology, University of Arizona, Tucson, USA; Evelyn F McKnight Brain Institute, Arizona Center on Aging, and BIO5 Institute, University of Arizona, Tucson, USA. Electronic address: yinghuichou@email.arizona.edu.
Mark SundmanBrain Imaging and TMS Laboratory, Department of Psychology, University of Arizona, Tucson, USA.
Viet Ton ThatBrain Imaging and TMS Laboratory, Department of Psychology, University of Arizona, Tucson, USA.
Jacob GreenBrain Imaging and TMS Laboratory, Department of Psychology, University of Arizona, Tucson, USA.
Chrisopher TrapaniBrain Imaging and TMS Laboratory, Department of Psychology, University of Arizona, Tucson, USA.
University of Arizona · US

Funding

Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic StimulationR01AG062543 · NIA · UNIVERSITY OF ARIZONA · PI CHOU, YING-HUI · 2020 to 2024
$3.5M
Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive ImpairmentR21AG077153 · NIA · UNIVERSITY OF ARIZONA · PI CHOU, YING-HUI · 2022 to 2023
$409k
NIA NIH HHS R01 AG062543NIA NIH HHS R21 AG077153
6 · The paper itself

Abstract

backgroundTranscranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique. When stimulation is applied over the primary motor cortex and coupled with electromyography measures, TMS can probe functions of cortical excitability and plasticity in vivo. The purpose of this meta-analysis is to evaluate the utility of TMS-derived measures for differentiating patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) from cognitively normal older adults (CN).

methodsDatabases searched included PubMed, Embase, APA PsycInfo, Medline, and CINAHL Plus from inception to July 2021.

resultsSixty-one studies with a total of 2728 participants (1454 patients with AD, 163 patients with MCI, and 1111 CN) were included. Patients with AD showed significantly higher cortical excitability, lower cortical inhibition, and impaired cortical plasticity compared to the CN cohorts. Patients with MCI exhibited increased cortical excitability and reduced plasticity compared to the CN cohort. Additionally, lower cognitive performance was significantly associated with higher cortical excitability and lower inhibition. No seizure events due to TMS were reported, and the mild adverse response rate is approximately 3/1000 (i.e., 9/2728).

conclusionsFindings of our meta-analysis demonstrate the potential of using TMS-derived cortical excitability and plasticity measures as diagnostic biomarkers and therapeutic targets for AD and MCI.

Indexed as

Alzheimer DiseaseCognitive DysfunctionCortical ExcitabilityAgedHumansNeuronal PlasticityTranscranial Magnetic StimulationAlzheimer's diseaseCortical excitabilityInhibitionMild cognitive impairmentPlasticityTranscranial magnetic stimulation

Identifiers

PMID35680080
PMCPMC9707650
OpenAlexW4281744112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.