Evidence map›Paper›PMID 35679923›Full record

ArticleThe Science of the total environment2022

Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model.

Christine E Crute, Samantha M Hall, Chelsea D Landon, Angela Garner, Jeffrey I Everitt, Sharon Zhang, Bevin Blake, Didrik Olofsson, Henry Chen, Susan K Murphy and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

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  6. Gestational arsenite exposure alters maternal postpartum heart size and induces CaAmerican journal of physiology. Heart and circulatory physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Christine E CruteIntegrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University, Durham, NC, USA; Nicholas School of the Environment, Duke University, Durham, NC, USA; Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA.
Samantha M HallIntegrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University, Durham, NC, USA; Nicholas School of the Environment, Duke University, Durham, NC, USA.
Chelsea D LandonDivision of Laboratory Animal Resources, Duke University Medical Center, Durham, NC, USA; Department of Pathology, Duke University School of Medicine, Duke University, Durham, NC, USA.
Angela GarnerDivision of Laboratory Animal Resources, Duke University Medical Center, Durham, NC, USA.
Jeffrey I EverittDivision of Laboratory Animal Resources, Duke University Medical Center, Durham, NC, USA; Department of Pathology, Duke University School of Medicine, Duke University, Durham, NC, USA.
Sharon ZhangNicholas School of the Environment, Duke University, Durham, NC, USA.
Bevin BlakeCurriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Didrik OlofssonOmiqa Bioinformatics GmbH, Altensteinstasse 40, 14195 Berlin, Germany.
Henry ChenDepartment of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA.
Susan K MurphyIntegrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University, Durham, NC, USA; Nicholas School of the Environment, Duke University, Durham, NC, USA; Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA.
Heather M StapletonIntegrated Toxicology and Environmental Health Program, Nicholas School of the Environment, Duke University, Durham, NC, USA; Nicholas School of the Environment, Duke University, Durham, NC, USA.
Liping FengNicholas School of the Environment, Duke University, Durham, NC, USA; Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA. Electronic address: liping.feng@duke.edu.
Duke University · USDuke University Hospital · USUniversity of North Carolina at Chapel Hill · US

Funding

Duke University Program in Environmental HealthT32ES021432 · NIEHS · DUKE UNIVERSITY · PI Akhenaton-Andrew Dhafir Jones, Joel Newman Meyer · 2013 to 2026
$4.0M
Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal developmentK01TW010828 · FIC · DUKE UNIVERSITY · PI FENG, LIPING · 2017 to 2021
$523k
FIC NIH HHS K01 TW010828NIEHS NIH HHS T32 ES021432
6 · The paper itself

Abstract

Mixtures of per- and polyfluoroalkyl substances (PFAS) are often found in drinking water, and serum PFAS are detected in up to 99% of the population. However, very little is known about how exposure to mixtures of PFAS affects maternal and fetal health. The aim of this study was to investigate maternal, fetal, and placental outcomes after preconceptional and gestational exposure to an environmentally relevant PFAS mixture in a New Zealand White (NZW) rabbit model. Dams were exposed via drinking water to control (no detectable PFAS) or a PFAS mixture for 32 days. This mixture was formulated with PFAS to resemble levels measured in tap water from Pittsboro, NC (10 PFAS compounds; total PFAS load = 758.6 ng/L). Maternal, fetal, and placental outcomes were evaluated at necropsy. Thyroid hormones were measured in maternal serum and kit blood. Placental gene expression was evaluated by RNAseq and qPCR. PFAS exposure resulted in higher body weight (p = 0.01), liver (p = 0.01) and kidney (p = 0.01) weights, blood pressure (p = 0.05), and BUN:CRE ratio (p = 0.04) in dams, along with microscopic changes in renal cortices. Fetal weight, measures, and histopathology were unchanged, but a significant interaction between dose and sex was detected in the fetal: placental weight ratio (p = 0.036). Placental macroscopic changes were present in PFAS-exposed dams. Dam serum showed lower T4 and a higher T3:T4 ratio, although not statistically significant. RNAseq revealed that 11 of the 14 differentially expressed genes (adj. p < 0.1) are involved in placentation or pregnancy complications. In summary, exposure elicited maternal weight gain and signs of hypertension, renal injury, sex-specific changes in placental response, and differential expression of genes involved in placentation and preeclampsia. Importantly, these are the first results to show adverse maternal and placental effects of an environmentally-relevant PFAS mixture in vivo.

Indexed as

Alkanesulfonic AcidsDrinking WaterEnvironmental PollutantsFluorocarbonsAnimalsFemaleHumansMaleMaternal ExposureNew ZealandPlacentaPregnancyRabbitsAlkanesulfonic AcidsDrinking WaterEnvironmental PollutantsFluorocarbonsPer- and polyfluoroalkyl substances (PFAS)PFAS mixturePlacental and birth outcomesRabbit

Identifiers

PMID35679923
PMCPMC9374364
OpenAlexW4281672433

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.