Evidence map›Paper›PMID 35679871›Full record

ArticleCurrent biology : CB2022

Brain-wide bidirectional neuropeptide modulation of individual neuron classes regulates a developmental decision.

Cynthia M Chai, Heenam Park, Paul W Sternberg

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. A multilayered gap junction network is essential for social decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Semantic Representation of Neural Circuit Knowledge inbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cynthia M ChaiDivision of Biology & Biological Engineering, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA 91125, USA. Electronic address: cchai@caltech.edu.
Heenam ParkDivision of Biology & Biological Engineering, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA 91125, USA.
Paul W SternbergDivision of Biology & Biological Engineering, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA 91125, USA. Electronic address: pws@caltech.edu.
California Institute of Technology · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Enhancing the C. elegans animal resource through genome editingR24OD023041 · OD · UNIVERSITY OF MINNESOTA · PI ROUGVIE, ANN E., STERNBERG, PAUL WARREN · 2017 to 2024
$5.1M
Comprehensive Analysis of a Decision CircuitUF1NS111697 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PEHLEVAN, CENGIZ, SAMUEL, ARAVINTHAN D. · 2019 to 2019
$3.0M
NIH HHS P40 OD010440NIH HHS R24 OD023041NINDS NIH HHS UF1 NS111697
6 · The paper itself

Abstract

Secreted neuromodulators, like biogenic amines and neuropeptides, can reconfigure circuit functions both locally and at a distance and establish global brain states that alter circuit outputs over prolonged timescales.

Indexed as

Caenorhabditis elegans ProteinsNeuropeptidesAnimalsBrainCaenorhabditis elegansNeuronsReceptors, NeuropeptideCaenorhabditis elegans ProteinsNeuropeptidesReceptors, Neuropeptidedecision-makingdevelopmental plasticitydiapauseG protein-coupled receptorneuropeptidesystems physiology

Identifiers

PMID35679871
PMCPMC10588560
OpenAlexW4282832449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.