Evidence map›Paper›PMID 35679858›Full record

ArticleCell systems2022

A molecular clock controls periodically driven cell migration in confined spaces.

Sung Hoon Lee, Jay C Hou, Archer Hamidzadeh, M Sulaiman Yousafzai, Visar Ajeti, Hao Chang, David J Odde, Michael Murrell, Andre Levchenko

Abstract read
PubMed Publisher
In one paragraph

Article in Cell systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Mesenchymal cell migration on one-dimensional micropatterns.Frontiers in cell and developmental biology · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Multiscale models of integrins and cellular adhesions.Current opinion in structural biology · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sung Hoon LeeYale Systems Biology Institute, Yale University, West Haven, CT 06516, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
Jay C HouDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Archer HamidzadehYale Systems Biology Institute, Yale University, West Haven, CT 06516, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
M Sulaiman YousafzaiYale Systems Biology Institute, Yale University, West Haven, CT 06516, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA; Department of Physics, Yale University, New Haven, CT 06520, USA.
Visar AjetiYale Systems Biology Institute, Yale University, West Haven, CT 06516, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA; Department of Physics, Yale University, New Haven, CT 06520, USA; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT 06032, USA.
Hao ChangYale Systems Biology Institute, Yale University, West Haven, CT 06516, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
David J OddeDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Michael MurrellYale Systems Biology Institute, Yale University, West Haven, CT 06516, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA; Department of Physics, Yale University, New Haven, CT 06520, USA.
Andre LevchenkoYale Systems Biology Institute, Yale University, West Haven, CT 06516, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA. Electronic address: andre.levchenko@yale.edu.
Yale University · USUniversity of Minnesota · USUConn Health · US

Funding

Systems analysis of phenotypic switch in control of cancer invasionU54CA209992 · NCI · YALE UNIVERSITY · PI LEVCHENKO, ANDRE · 2016 to 2021
$10.1M
Project 2: Cell Migration in Mechanically Complex MicroenvironmentsU54CA210190 · NCI · UNIVERSITY OF MINNESOTA · PI LARGAESPADA, DAVID ANDREW, ODDE, DAVID J. · 2016 to 2020
$10.0M
Project 3P01CA254849 · NCI · UNIVERSITY OF MINNESOTA · PI ODDE, DAVID J. · 2021 to 2025
$9.4M
NCI NIH HHS P01 CA254849NCI NIH HHS U54 CA209992NCI NIH HHS U54 CA210190
6 · The paper itself

Abstract

Navigation through a dense, physically confining extracellular matrix is common in invasive cell spread and tissue reorganization but is still poorly understood. Here, we show that this migration is mediated by cyclic changes in the activity of a small GTPase RhoA, which is dependent on the oscillatory changes in the activity and abundance of the RhoA guanine nucleotide exchange factor, GEF-H1, and triggered by a persistent increase in the intracellular Ca

Indexed as

Confined SpacesMicrotubulesCell MovementRho Guanine Nucleotide Exchange FactorsRho Guanine Nucleotide Exchange Factorscell migrationcomputational modelconfining spacesGEF-H1intracellular calciummicrotubule dynamicsmolecular clocknegative feedbackoscillationsRhoA guanine exchange factor

Identifiers

PMID35679858
OpenAlexW4282919410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.