Evidence map›Paper›PMID 35679806›Full record

ArticleNeurobiology of aging2022

Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample.

Patrick J Lao, Amelia K Boehme, Clarissa Morales, Krystal K Laing, Anthony Chesebro, Kay C Igwe, Jose Gutierrez, Yian Gu, Yaakov Stern, Nicole Schupf and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Association of type 2 diabetes treatment status with in vivo biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Article
  5. Racial/ethnic differences in the association of lifestyle factors with biological aging in NHANES, 1999-2018.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Patrick J LaoDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Amelia K BoehmeDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Clarissa MoralesDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Krystal K LaingDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Anthony ChesebroDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Kay C IgweDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jose GutierrezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Yian GuDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.
Yaakov SternDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Nicole SchupfDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.
Jennifer J ManlyDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.
Richard MayeuxDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Adam M BrickmanDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: amb2139@columbia.edu.
Columbia University · US

Funding

VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SCHUPF, NICOLE · 1989 to 2008
$21.7M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Resilience Mechanisms Underlying Racial/Ethnic Disparities in Alzheimer’s DiseaseR01AG054520 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, ZAHODNE, LAURA B · 2017 to 2021
$5.8M
White matter hyperintensities in Aging and DementiaR01AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2010 to 2014
$2.0M
White Matter Hyperintentisities in Aging and DementiaR56AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2016 to 2016
$793k
Understanding the mechanisms linking small vessel cerebrovascular disease and Alzheimer's disease pathophysiology with neurodegeneration and cognition during midlifeR00AG065506 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAO, PATRICK JORDAN · 2023 to 2025
$742k
Understanding the mechanisms linking small vessel cerebrovascular disease and Alzheimer's disease pathophysiology with neurodegeneration and cognition during midlifeK99AG065506 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAO, PATRICK JORDAN · 2020 to 2021
$260k
NIA NIH HHS K99 AG065506NIA NIH HHS P01 AG007232NIA NIH HHS R00 AG065506NIA NIH HHS R01 AG034189NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG054520NIA NIH HHS R01 AG072474NIA NIH HHS R56 AG034189NIA NIH HHS RF1 AG054023
6 · The paper itself

Abstract

We characterized the additive contribution of cerebrovascular biomarkers to amyloid and neurodegeneration biomarkers (AV(N)) when modeling prospective, longitudinal cognitive trajectories within 3 major racial/ethnic groups. Participants (n = 172; age = 69-96 years; 62% women; 31%/49%/20% Non-Hispanic White/Non-Hispanic Black/Hispanic) from the Washington Heights-Inwood Columbia Aging Project were assessed for amyloid (Florbetaben PET), neurodegeneration (cortical thickness, hippocampal volume), and cerebrovascular disease (white matter hyperintensity (WMH), infarcts). Neuropsychological assessments occurred every 2.3 ± 0.6 years for up to 6 visits (follow-up time: 4.2 ± 3.2 years). Linear mixed-effects models were stratified by race/ethnicity groups. Higher amyloid was associated with faster memory decline in all 3 racial/ethnic groups, but was related to faster cognitive decline beyond memory in minoritized racial/ethnic groups. Higher WMH was associated with faster language, processing speed/executive function, and visuospatial ability decline in Non-Hispanic Black participants, while infarcts were associated with faster processing speed/executive function decline in Non-Hispanic White participants. Complementary information from AD, neurodegenerative, and cerebrovascular biomarkers explain decline in multiple cognitive domains, which may differ within each racial/ethnic group. Importantly, treatment strategies exist to minimize vascular contributions to cognitive decline.

Indexed as

Alzheimer DiseaseAmyloidosisCerebrovascular DisordersCognitive DysfunctionAgedAged, 80 and overAmyloidBiomarkersCognitionFemaleHumansInfarctionMagnetic Resonance ImagingMaleNeuropsychological TestsProspective StudiesAmyloidBiomarkersAlzheimer's diseaseCerebrovascular diseaseCognitive declineNeuroimagingRace/Ethnicity

Identifiers

PMID35679806
PMCPMC9997572
OpenAlexW4280549154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.