Evidence map›Paper›PMID 35679616›Full record

ReviewAnnual review of microbiology2022

The Small-Molecule Language of Dynamic Microbial Interactions.

Yifan Zhang, Étienne Gallant, Jong-Duk Park, Mohammad R Seyedsayamdost

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Microbial community assembly in the fermentation of cigar tobacco leaves.Frontiers in bioengineering and biotechnology · 2026
    Review
  3. Iron limitation triggers roseoceramide biosynthesis and membrane remodeling in marine roseobacter.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yifan ZhangDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA; email: yz18@princeton.edu, mrseyed@princeton.edu.
Étienne GallantDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA; email: egallant@princeton.edu, jdpark@princeton.edu.
Jong-Duk ParkDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA; email: egallant@princeton.edu, jdpark@princeton.edu.
Mohammad R SeyedsayamdostDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA; email: yz18@princeton.edu, mrseyed@princeton.edu.

Funding

Exploring a New Dimension of Microbial Secondary MetabolismR01GM140034 · NIGMS · PRINCETON UNIVERSITY · PI SEYEDSAYAMDOST, MOHAMMAD R · 2021 to 2024
$1.2M
Molecular Analysis of Metabolites and Signaling Networks in Microbial SymbiosesR00GM098299 · NIGMS · PRINCETON UNIVERSITY · PI SEYEDSAYAMDOST, MOHAMMAD R · 2013 to 2015
$747k
Molecular Analysis of Metabolites and Signaling Networks in Microbial SymbiosesK99GM098299 · NIGMS · HARVARD MEDICAL SCHOOL · PI SEYEDSAYAMDOST, MOHAMMAD R · 2011 to 2012
$135k
NIGMS NIH HHS K99 GM098299NIGMS NIH HHS R00 GM098299NIGMS NIH HHS R01 GM140034
6 · The paper itself

Abstract

Although microbes are routinely grown in monocultures in the laboratory, they are almost never encountered as single species in the wild. Our ability to detect and identify new microorganisms has advanced significantly in recent years, but our understanding of the mechanisms that mediate microbial interactions has lagged behind. What makes this task more challenging is that microbial alliances can be dynamic, consisting of multiple phases. The transitions between phases, and the interactions in general, are often mediated by a chemical language consisting of small molecules, also referred to as secondary metabolites or natural products. In this microbial lexicon, the molecules are like words and through their effects on recipient cells they convey meaning. The current review highlights three dynamic microbial interactions in which some of the words and their meanings have been characterized, especially those that mediate transitions in selected multiphasic associations. These systems provide insights into the principles that govern microbial symbioses and a playbook for interrogating similar associations in diverse ecological niches.

Indexed as

Biological ProductsMicrobial InteractionsEcosystemSymbiosisBiological Productsantibioticsinterspecies interactionsnatural productsecondary metabolitesymbiosis

Identifiers

PMID35679616
PMCPMC10171915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.