ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Natural History Trajectories of Frailty in Community-Dwelling Older Japanese Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Three-time-point directional patterns of frailty and physical function in older adults participating in community gathering places in Koshigaya City, Japan: a retrospective exploratory study.Preventive medicine reports · 2026Article
- Article
- Validation and refinement of a biomarker panel for frailty assessment and prediction of muscle weakness in older adults.npj aging · 2026Article
- A frailty-intrinsic capacity index to predict disability in community-dwelling older Japanese adults.JAR life · 2025Article
- Relationship Between COPD Progression and Frailty Progression: A Five-year Observation in Real Clinical Practice.International journal of chronic obstructive pulmonary disease · 2025Observational
- Effect of leisure activity on frailty trajectories among Chinese older adults: a 16-year longitudinal study.BMC geriatrics · 2024Article
- Effects of cigarette smoking and secondhand smoke exposure on physical frailty development among community-dwelling older adults in Japan: Evidence from a 10-year population-based cohort study.Geriatrics & gerontology international · 2024Article
- Dual trajectories of social participation and frailty in Chinese older adults: a longitudinal study based on CLHLS from 2008 to 2018.Frontiers in public health · 2024Article
- Factors associated with weight loss by age among community-dwelling older people.BMC geriatrics · 2023Article
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Authors and funding
7 authors.
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Abstract
backgroundThe gap between the average life expectancy and healthy life expectancy remains wide. Understanding the natural history of frailty development is necessary to prevent and treat frailty to overcome this gap. This study elucidated the trajectories of 5 frailty assessment components using group-based multitrajectory modeling.
methodsOverall, 845 community-dwelling older adults (aged 65-91 years; 433 males and 412 females) who underwent longitudinal frailty assessments at least 3 times were included in the analysis. The mean follow-up period (±SD, range) was 7.1 (±2.3, 3.8-11.3) years. In each wave, the physical frailty was assessed for the following 5 partially modified components of the Cardiovascular Health Study criteria: shrinking, weakness, exhaustion, slowness, and low activity. Using group-based multitrajectory modeling, we identified subgroups that followed distinctive trajectories regarding the 5 frailty components.
resultsFive frailty trajectory groups were identified: weakness-focused frail progression group (Group 1 [G1]; 10.9%), robust maintenance group (Group 2 [G2]; 43.7%), exhaustion-focused prefrail group (Group 3 [G3]; 24.3%), frail progression group (Group 4 [G4]; 6.7%), and low activity-focused prefrail group (Group 5 [G5]; 14.4%). The Cox proportional hazards model analysis showed that G1, G4, and G5 had significantly higher mortality risks after adjusting for sex and age (G2 was the reference group).
conclusionBased on the natural history of frailty, the 5 distinctive trajectory groups showed that some individuals remained robust, while others remained predominantly prefrail or progressed primarily owing to physical mobility decline. Therefore, identifying individuals belonging to these progressive frailty groups and providing interventions according to the characteristics of each group may be beneficial.
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