Evidence map›Paper›PMID 35679539›Full record

Observational studyPloS one2022

Chronic kidney disease in cancer patients, the analysis of a large oncology database from Eastern Europe.

Mircea Ciorcan, Lazar Chisavu, Adelina Mihaescu, Florica Gadalean, Flaviu Raul Bob, Serban Negru, Oana Marina Schiller, Iulia Dana Grosu, Luciana Marc, Flavia Chisavu and 4 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

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  15. Sex differences in cancer outcomes across the range of eGFR.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mircea CiorcanDepartment of Clinical Practical Skills, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.ORCID 0000-0002-8395-1009
Lazar ChisavuDivision of Nephrology, Dept. of Internal Medicine II, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, Romania.
Adelina MihaescuDivision of Nephrology, Dept. of Internal Medicine II, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, Romania.ORCID 0000-0002-3220-6623
Florica GadaleanDivision of Nephrology, Dept. of Internal Medicine II, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, Romania.
Flaviu Raul BobDivision of Nephrology, Dept. of Internal Medicine II, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, Romania.
Serban NegruOncohelp Medical Center Timisoara, Oncology, Timisoara, Romania, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.
Oana Marina SchillerAvitum BBraun Romania Timisoara, Nephrology, Timisoara, Romania.
Iulia Dana GrosuDivision of Nephrology, Dept. of Internal Medicine II, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, Romania.
Luciana MarcDivision of Nephrology, Dept. of Internal Medicine II, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, Romania.
Flavia ChisavuEmergency Hospital for Children Louis Turcanu Timisoara, Pediatric Nephrology, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.
Razvan Dragota PascotaCounty Emergency Clinical Hospital, Nephrology, Timisoara, Romania.
Adrian ApostolCentre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.
Viviana IvanCentre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.
Adalbert SchillerDivision of Nephrology, Dept. of Internal Medicine II, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, Romania.
Victor Babeș University of Medicine and Pharmacy Timișoara · ROClinical Emergency Hospital Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKidney dysfunction is prevalent in oncology patients and has an impact on their treatment and quality of life. The aim of our study was to analyze the prevalence of CKD in a large cohort of several types of cancer patients in an East European Region. MATERIAL AND

methodsWe conducted an observational retrospective cohort study on 5831 consecutive, biopsy-diagnosed cancer patients between January 2019 -December 2020 in the largest oncology hospital and outpatient clinic in Western Romania. 4342 subjects were included in the statistical analysis. RESULTS AND DISCUSSION: From the 24 cancer types, the most prevalent cancers were represented by: breast (22.02%), lung (10.18%) and colonic cancer (9.51%). The prevalence of CKD (G3 -G5) was 12.27% after the first year of follow-up and 13.42 after the second year. The prevalence of CKD was higher in patients with renal (50%), urinary tract (33.6%) and pancreatic cancers (19.6%) and lower in patients with colonic cancers (5.3%) and brain tumors (2.5%). At the end of our 2-year survey period, 0,7% of the CKD cases had an eGFR around 6 ml/min/1.73m2 -an indication for renal replacement therapy.

conclusionOncology patients have a significantly higher prevalence of CKD compared to the general population, dependent of the age of the patients and the type of cancer. The prevalence of advanced CKD was surprisingly high (stages G4-G5 Pre-Dialysis 22.15%) one third of the CKD- G5 patients having indication for initiation of renal replacement therapy. An onco- nephrology team should be needed for the best medical care of these patients.

Indexed as

NeoplasmsRenal Insufficiency, ChronicDisease ProgressionGlomerular Filtration RateHumansQuality of LifeRetrospective Studies

Identifiers

PMID35679539
PMCPMC9183451
OpenAlexW4285413250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.