ReviewPhysiological reviews2022
Human temperature regulation under heat stress in health, disease, and injury.
Review in Physiological reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
167 citing papers in PubMed, 5 syntheses or guidelines pooled it, 387 citations in OpenAlex.
- Building the model: a review of input structures in extreme temperature-health.Environmental health : a global access science source · 2026Pooled it
- An Umbrella Review of Systematic Reviews and Meta-Analyses on Occupational Heat Exposure, Health Risks, and Productivity Losses Globally.Current environmental health reports · 2026Pooled it
- Hyperthermia during open water swimming: risks, monitoring and mitigation strategies.European journal of applied physiology · 2025Pooled it
- Heat Adaptation for Females: A Systematic Review and Meta-Analysis of Physiological Adaptations and Exercise Performance in the Heat.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Wearable Sensor Technology to Predict Core Body Temperature: A Systematic Review.Sensors (Basel, Switzerland) · 2022Pooled it
- Ketone monoester ingestion and cognitive and physical performance during exercise-heat stress.Journal of the International Society of Sports Nutrition · 2026Trial
- Postural Instability Is Greater in Men with Type 2 Diabetes after Exertional Heat Stress.Medicine and science in sports and exercise · 2026Trial
- Effects of Heat Exposure on Kynurenine Pathway Metabolism-Comparison Between Exertional and Exogenous Heating of the Human Body.Acta physiologica (Oxford, England) · 2025Trial
- Medical mud-pack treatment with different temperatures in patients with knee osteoarthritis.International journal of biometeorology · 2025Trial
- Active Heat Acclimation Training Offered Better Results in Thermal Rooms in Basic-Training Troops: A Prospective Controlled Study.Inquiry : a journal of medical care organization, provision and financingTrial
- Heat, menstruation, and mental health in adolescence and young adulthood: Understudied in climate-health research.Dialogues in health · 2026Review
- Endoscopic sympathectomy impairs forearm cutaneous vascular conductance and sweating responses during passive whole body heat stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Social Physiology: Human homeostasis is more efficient in social proximity.Science advances · 2026Article
- Article
- Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling.Molecular medicine reports · 2026Article
- Who Can Avoid the Heat? Inter-Individual Differences in 24-hr Heat Exposure Reveal Disparities in Heat Adaptation and Stress.GeoHealth · 2026Article
- Accuracy of next-generation wireless skin temperature sensors during exercise-heat stress.Experimental physiology · 2026Article
- Radon balneotherapy in rheumatologic diseases: potential mechanisms and implications for cardiovascular autonomic control and inflammation.Clinical rheumatology · 2026Review
- A practical approach to illustrate the importance of the bodily energy and heat balances and of the associated regulatory loops to healthcare students.BMC medical education · 2026Article
- Comparison of exercise training and repeated hot water immersion on vascular function in overweight older adults.Experimental physiology · 2026Article
107 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
The human body constantly exchanges heat with the environment. Temperature regulation is a homeostatic feedback control system that ensures deep body temperature is maintained within narrow limits despite wide variations in environmental conditions and activity-related elevations in metabolic heat production. Extensive research has been performed to study the physiological regulation of deep body temperature. This review focuses on healthy and disordered human temperature regulation during heat stress. Central to this discussion is the notion that various morphological features, intrinsic factors, diseases, and injuries independently and interactively influence deep body temperature during exercise and/or exposure to hot ambient temperatures. The first sections review fundamental aspects of the human heat stress response, including the biophysical principles governing heat balance and the autonomic control of heat loss thermoeffectors. Next, we discuss the effects of different intrinsic factors (morphology, heat adaptation, biological sex, and age), diseases (neurological, cardiovascular, metabolic, and genetic), and injuries (spinal cord injury, deep burns, and heat stroke), with emphasis on the mechanisms by which these factors enhance or disturb the regulation of deep body temperature during heat stress. We conclude with key unanswered questions in this field of research.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.