Evidence map›Paper›PMID 35679351›Full record

ArticleThe Journal of infectious diseases2023

Control of Epstein-Barr Virus (EBV) in the Oral Cavity Is Associated With Persistence of Oral Human Papillomavirus (HPV)16/18 Among Men From the HPV Infection in Men Study.

Brittney L Dickey, Anna R Giuliano, Bradley Sirak, Martha Abrahamsen, Eduardo Lazcano-Ponce, Luisa L Villa, Anna E Coghill

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Epstein-Barr Virus Serology Associated With Persistent Oral Human Papillomavirus Infections in Men.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025
    Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Brittney L DickeyDepartment of Cancer Epidemiology and Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Anna R GiulianoDepartment of Cancer Epidemiology and Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Bradley SirakDepartment of Cancer Epidemiology and Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Martha AbrahamsenDepartment of Cancer Epidemiology and Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Eduardo Lazcano-PonceCenter for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Luisa L VillaDepartment of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo e Instituto do Cancer do Estado de São Paulo, São Paulo, Brazil.
Anna E CoghillDepartment of Cancer Epidemiology and Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Moffitt Cancer Center · USInstituto Nacional de Salud Pública · MXUniversidade de São Paulo · BR

Funding

Investigation of Oral HPV Infection Natural History and Biomarkers of Persistent Infection: The HIM StudyR01CA214588 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GIULIANO, ANNA R. · 2017 to 2021
$3.6M
Moffitt Postdoctoral Training Program in Molecular EpidemiologyT32CA147832 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KANETSKY, PETER A · 2015 to 2019
$659k
NCI NIH HHS R01 CA214588NCI NIH HHS T32 CA147832NIH HHS R01 CA214588
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV)-related oropharyngeal cancer (OPC) incidence is increasing among men. Biomarkers that can identify oral HPV16/18 infections likely to persist, the obligate precursor for HPV-OPC, are needed.

methodsWe assessed the association between oral Epstein-Barr virus (EBV) and oral HPV16/18 persistence among 63 men in the HPV Infection in Men Study who tested positive for HPV16/18 at the baseline visit. Control of oral coinfections, including EBV, could serve as a biomarker of immune competence and the ability to control oral HPV.

resultsDetection of oral EBV was significantly associated with oral HPV16/18 ≥12-month persistence.

conclusionsDetection of oral EBV deserves evaluation as a biomarker for oral HPV persistence and HPV-related OPC.

Indexed as

Epstein-Barr Virus InfectionsMouth DiseasesOropharyngeal NeoplasmsPapillomavirus InfectionsHerpesvirus 4, HumanHuman papillomavirus 16Human papillomavirus 18Human Papillomavirus VirusesHumansMalePapillomaviridaeEBVHPV16/18OPCoral HPV persistence

Identifiers

PMID35679351
PMCPMC10202421
OpenAlexW4281760882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.