Evidence map›Paper›PMID 35678881›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

The association between cancer-related fatigue and diabetes from pre-chemotherapy to 6 months post-chemotherapy.

Amber S Kleckner, Ian R Kleckner, Eva Culakova, Michelle Shayne, Elizabeth K Belcher, Abdi T Gudina, AnnaLynn M Williams, Adedayo A Onitilo, Judith O Hopkins, Howard Gross and 3 more

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01382082 (Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy at Pre-Treatment, Post-Treatment, at Six Month Follow-Up, and Long-Term Follow-Ups), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01382082 active not recruitingnot on this map

Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy at Pre-Treatment, Post-Treatment, at Six Month Follow-Up, and Long-Term Follow-Ups

TypeobservationalSponsorUniversity of Rochester NCORP Research BaseRan2011 to 2026Enrolled1,432ConditionsBreast Cancer, Lymphoma
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. The impact of hyperglycaemia and/or type 2 diabetes on women with breast cancer undergoing or post-cytotoxic chemotherapy: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. The impact of integrative medicine on quality of life in patients with diabetes mellitus and cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  3. Time-restricted eating to address persistent cancer-related fatigue among cancer survivors: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  4. Article
  5. Relationship between fatigue and self-compassion and associated factors in patients with hematological cancer: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Observational
  6. The role of glycemic control and symptoms and symptom clusters in breast cancer survivors with type 2 diabetes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Metabolic underpinnings of cancer-related fatigue.American journal of physiology. Endocrinology and metabolism · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Amber S KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, 655 W. Lombard Ave., 7th floor, Baltimore, MD, 21201, USA. amber.kleckner@umaryland.edu.ORCID http://orcid.org/0000-0002-5088-1139
Ian R KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, 655 W. Lombard Ave., 7th floor, Baltimore, MD, 21201, USA.ORCID http://orcid.org/0000-0002-9828-9986
Eva CulakovaDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-9852-6515
Michelle ShayneDepartment of Medicine, University of Rochester Medical Center, 265 Crittenden Blvd. CU 420658, Rochester, NY, 14642, USA.
Elizabeth K BelcherDepartment of Psychological Science, Hobart and William Smith Colleges, Geneva, NY, USA.ORCID http://orcid.org/0000-0003-2071-7351
Abdi T GudinaDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
AnnaLynn M WilliamsDepartment of Epidemiology & Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-7042-5851
Adedayo A OnitiloWisconsin NCORP, Marshfield Medical Center, Weston, WI, USA.ORCID http://orcid.org/0000-0001-9185-0606
Judith O HopkinsSoutheast Clinical Oncology Research (SCOR) Consortium, Winston-Salem, Weston, NC, USA.ORCID http://orcid.org/0000-0002-9829-1242
Howard GrossDayton Clinical Oncology Program, Dayton, OH, USA.
Karen M MustianDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-6525-7518
Luke J PepponeDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-0346-5191
Michelle C JanelsinsDivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA. michelle_janelsins@urmc.rochester.edu.ORCID http://orcid.org/0000-0003-2258-7247
University of Rochester Medical Center · USUniversity of Maryland, Baltimore · USDayton Clinical Oncology Program · USHobart and William Smith Colleges · USMarshfield Clinic Weston Center · USSoutheast Clinical Oncology Research Consortium · USSt. Jude Children's Research Hospital · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Translational Neuroscience Approaches to Cancer-Related Cognitive Impairment: Measurement, Mechanisms, and FunctionR01CA231014 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2019 to 2024
$3.1M
Clinical and Translational Cancer Control Research Training ProgramT32CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, Gary R Morrow · 2019 to 2026
$2.7M
The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy, Inflammation, and Interoceptive Brain CircuitryK07CA221931 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT · 2018 to 2022
$795k
NCI NIH HHS K07 CA221931NCI NIH HHS K07CA221931NCI NIH HHS R01 CA231014NCI NIH HHS R01CA231014NCI NIH HHS T32 CA102618NCI NIH HHS T32CA102618NCI NIH HHS UG1 CA189961NCI NIH HHS UG1CA189961
6 · The paper itself

Abstract

purposeTo quantify the relationship between diabetes and fatigue from pre-chemotherapy to 6 months post-chemotherapy for women with breast cancer compared to women without a history of cancer (controls).

methodsThis was a secondary analysis from a nationwide prospective longitudinal study of female patients with breast cancer undergoing chemotherapy and controls. Diabetes diagnosis (yes/no) was obtained at baseline, and cancer-related fatigue was measured using the Multidimensional Fatigue Symptom Inventory (MFSI) pre-, post-, and 6 months post-chemotherapy in patients; controls were assessed at equivalent time points. Repeated measures mixed effects models estimated the association between fatigue and diabetes controlling for cancer (yes/no), body mass index, exercise and smoking habits, baseline anxiety and depressive symptoms, menopausal status, marital status, race, and education.

resultsAmong 439 patients and 235 controls (52.8 ± 10.5 years old), diabetes was twice as prevalent among patients as controls (11.6% vs. 6.8%). At baseline, diabetes was associated with worse fatigue (4.1 ± 1.7 points, p = 0.017). Also, diabetes was associated with clinically meaningful worse fatigue throughout the study period among all participants (5.2 ± 1.9 points, p = 0.008) and patients alone (4.5 ± 2.0, p = 0.023). For the MFSI subdomains among patients, diabetes was associated with worse general (p = 0.005) and mental fatigue (p = 0.026).

conclusionsDiabetes was twice as prevalent in women with breast cancer compared to controls, and diabetes was associated with more severe cancer-related fatigue in patients before and after chemotherapy and at 6 months post-chemotherapy. Interventions that address diabetes management may also help address cancer-related fatigue during chemotherapy treatment.

trial registrationClinicalTrials.gov identifier: NCT01382082, first posted June 27, 2011.

Indexed as

Breast NeoplasmsDiabetes MellitusAdultAnxietyFatigueFemaleHumansLongitudinal StudiesMiddle AgedProspective StudiesQuality of LifeCancer-related fatigueChemotherapyDiabetesMetabolismSupportive care

Identifiers

PMID35678881
PMCPMC10079326
OpenAlexW4281619859

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.