Evidence map›Paper›PMID 35678874›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Acinic cell carcinoma of the parotid gland: Timeo Danaos et dona ferentes? A multicenter retrospective analysis focusing on survival outcome.

Pietro De Luca, Luca de Campora, Domenico Tassone, Francesca Atturo, Roberta Colangeli, Gerardo Petruzzi, Matteo Fermi, Giulia Molinari, Andi Abeshi, Giulia Cintoli and 21 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. 3D exoscopic assisted parotidectomy: practical considerations from a preliminary case series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  2. Article
  3. Parotid Gland Tumors: Molecular Diagnostic Approaches.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Systematic Review of Management and Survival Outcome of Parotid Cancers with Lateral Skull Base Invasion.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  7. Article
  8. Review
  9. In Reference to "Surgical Outcomes of U-Shaped Incisions Versus Conventional Incisions in Parotidectomy".Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 16 institutions in 1 country.

Pietro De Luca *Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy. dr.dlp@hotmail.it.ORCID http://orcid.org/0000-0002-6505-1680
Luca de Campora *Department Otolaryngology Head and Neck Surgery, San Giovanni-Addolorata Hospital, Rome, Italy.
Domenico TassoneDepartment Otolaryngology Head and Neck Surgery, San Giovanni-Addolorata Hospital, Rome, Italy.
Francesca AtturoDepartment Otolaryngology Head and Neck Surgery, San Giovanni-Addolorata Hospital, Rome, Italy.
Roberta ColangeliDepartment Otolaryngology Head and Neck Surgery, San Giovanni-Addolorata Hospital, Rome, Italy.
Gerardo PetruzziDepartment Otolaryngology Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy.
Matteo FermiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Giulia MolinariDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Andi AbeshiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Giulia CintoliDepartment of Otolaryngology-Head and Neck Surgery, University of Foggia, Foggia, Italy.
Alfredo Lo MantoDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Giulia TogoMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Naples, Italy.
Filippo RicciardielloOtolaryngology Department, AORN Cardarelli, Naples, Italy.
Paolo CondorelliOtolaryngology Department, AORN Garibaldi, Catania, Italy.
Ferdinando RasoOtolaryngology Department, AORN Garibaldi, Catania, Italy.
Arianna Di StadioOtolaryngology Department, University of Catania, Catania, Italy.
Giovanni SalzanoOtolaryngology and Maxillo-Facial Surgery Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples, Italy.
Erik EspositoOtolaryngology Department, ASL Napoli 3 Sud, Torre del Greco, Naples, Italy.
Aurelio D'EcclesiaIRCCS "Casa Sollievo Della Sofferenza" San Giovanni Rotondo, Foggia, Italy.
Marco RadiciUnit of Otolaryngology, S. Giovanni Calibita-Fatebenefratelli General Hospital, Rome, Italy.
Maurizio IemmaOtolaryngology Department, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Salerno, Italy.
Maurizio Giovanni VigiliDepartment of General Surgery-Head and Neck Consultant, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Rome, Italy.
Francesco Antonio SalzanoDepartment of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
Luciano MagaldiDepartment of Otolaryngology-Head and Neck Surgery, University of Foggia, Foggia, Italy.
Michele CassanoDepartment of Otolaryngology-Head and Neck Surgery, University of Foggia, Foggia, Italy.
Iacopo DallanDepartment of Otorhinolaryngology, Azienda Ospedaliera Universitaria, Pisa, Italy.
Raul PelliniDepartment Otolaryngology Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy.
Livio PresuttiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Franco IonnaOtolaryngology and Maxillo-Facial Surgery Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples, Italy.
Enrico de CamporaAssociazione Ospedaliera Italia Centromeridionale Otorinolaringoiatrica (AOICO), Rome, Italy.
Angelo CamaioniDepartment Otolaryngology Head and Neck Surgery, San Giovanni-Addolorata Hospital, Rome, Italy.
Azienda Ospedaliera San Giovanni Addolorata · ITAzienda USL di Bologna · ITUniversity of Foggia · ITIstituti Fisioterapici Ospitalieri · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITOspedale Garibaldi · ITUniversity of Salerno · ITAzienda Ospedaliera Universitaria Pisana · ITAzienda Ospedaliero Universitaria Ospedali Riuniti · ITCasa Sollievo della Sofferenza · ITFatebenefratelli Hospital · ITIstituto Dermopatico dell'Immacolata · ITOspedale Antonio Cardarelli · ITOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · ITUniversity of Catania · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyze the demographic data, surgical and adjuvant treatment data and the survival outcomes in adult patients affected by acinic cell carcinoma of the parotid gland (AciCC).

methodsA retrospective multicenter analysis of patients treated for AciCC of the parotid gland from 2000 to 2021 was performed. Exclusion criteria were pediatric (0-18 years) patients, the absence of follow-up and patients with secondary metastatic disease to the parotid gland. Multivariable logistic regression was used to determine factors associated with survival.

resultsThe study included 81 adult patients with AciCC of the parotid gland. The median age was 46.3 years (SD 15.81, range 19-84 years), with a gender female prevalence (F = 48, M = 33). The mean follow-up was 77.7 months (min 4-max 361, SD 72.46). The 5 years overall survival (OS) was 97.5%. The 5 years disease-free survival (DFS) was 60%. No statistical differences have been found in prognosis for age (< 65 or ≥ 65 years), sex, surgery type (superficial vs profound parotid surgery), radicality (R0 vs R1 + Rclose), neck dissection, early pathologic T and N stages and adjuvant therapy (p > 0.05).

conclusionThis study did not find prognostic factor for poorest outcome. In contrast with the existing literature, our results showed how also high-grade tumours cannot be considered predictive of recurrence or aggressive behaviour.

Indexed as

Carcinoma, Acinar CellParotid NeoplasmsAdultAgedAged, 80 and overChildFemaleGlucosamineHumansMiddle AgedNeoplasm StagingParotid GlandPrognosisRetrospective StudiesYoung AdultGlucosamineAcinic cell carcinomaMajor salivary gland tumourParotid cancerParotid gland

Identifiers

PMID35678874
PMCPMC9649501
OpenAlexW4282928285

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.