Evidence map›Paper›PMID 35678711›Full record

ArticleAnalytical chemistry2022

Multiplexed Monitoring of Neurochemicals via Electrografting-Enabled Site-Selective Functionalization of Aptamers on Field-Effect Transistors.

Zan Gao, Guangfu Wu, Yang Song, Huijie Li, Yuxuan Zhang, Michael J Schneider, Yingqi Qiang, Jackson Kaszas, Zhengyan Weng, He Sun and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
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  8. In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025
    Article
  9. Review
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  11. Review
  12. PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  13. Review
  14. Article
  15. Long-TermbioRxiv : the preprint server for biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Zan GaoDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.
Guangfu WuDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.
Yang SongDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0003-0626-0850
Huijie LiDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.
Yuxuan ZhangDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.
Michael J SchneiderDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0003-1435-1584
Yingqi QiangDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0001-8763-2323
Jackson KaszasDepartment of Materials Science and Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.
Zhengyan WengDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.
He SunDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.
Bryan D HueyDepartment of Materials Science and Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.
Rebecca Y LaiDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.ORCID 0000-0002-1732-9481
Yi ZhangDepartment of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0002-0907-663X
University of Connecticut · USUniversity of Nebraska–Lincoln · US

Funding

A Wireless, Closed-Loop Neural Probe for Optogenetics, Pharmacology and Neurochemical MonitoringRF1NS118287 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI ZHANG, YI · 2020 to 2020
$3.3M
NINDS NIH HHS RF1 NS118287
6 · The paper itself

Abstract

Neurochemical corelease has received much attention in understanding brain activity and cognition. Despite many attempts, the multiplexed monitoring of coreleased neurochemicals with spatiotemporal precision and minimal crosstalk using existing methods remains challenging. Here, we report a soft neural probe for multiplexed neurochemical monitoring via the electrografting-assisted site-selective functionalization of aptamers on graphene field-effect transistors (G-FETs). The neural probes possess excellent flexibility, ultralight mass (28 mg), and a nearly cellular-scale dimension of 50 μm × 50 μm for each G-FET. As a demonstration, we show that G-FETs with electrochemically grafted molecular linkers (-COOH or -NH

Indexed as

DopamineGraphiteAnimalsBrainMiceNorepinephrineOligonucleotidesRatsSerotoninDopamineGraphiteNorepinephrineOligonucleotidesSerotonin

Identifiers

PMID35678711
PMCPMC9480490
OpenAlexW4282014793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.