Evidence map›Paper›PMID 35678643›Full record

Observational studyThe Journal of infectious diseases2022

Impact of Oxidative Stress on Risk of Death and Readmission in African Children With Severe Malaria: A Prospective Observational Study.

Daniel B Blatt, Benjamin Hanisch, Katrina Co, Dibyadyuti Datta, Caitlin Bond, Robert O Opoka, Sarah E Cusick, Ian C Michelow, Chandy C John

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01093989 (Acute vs. Delayed Iron Therapy), which is not on this map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01093989 nacompletednot on this map

Acute vs. Delayed Iron Therapy: Effect on Iron Status, Anemia and Cognition

TypeinterventionalSponsorUniversity of MinnesotaRan2010 to 2014Enrolled239ConditionsAnemia, Inflammation, Malaria Morbidity, Cognitive DevelopmentArmsFerrous Sulphate Syrup
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Increased Blood Concentrations of Malondialdehyde inAntioxidants (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Daniel B BlattDepartment of Pediatrics, Division of Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Benjamin HanischDepartment of Pediatrics, Division of Infectious Diseases, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.ORCID 0000-0003-3387-9093
Katrina CoDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Dibyadyuti DattaDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-1693-935X
Caitlin BondDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Robert O OpokaDepartment of Paediatrics and Child Health, Makerere University, Kampala, Uganda.
Sarah E CusickDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Ian C MichelowDepartment of Pediatrics, Division of Infectious Diseases, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Hartford, Connecticut, USA.ORCID 0000-0002-8399-480X
Chandy C JohnDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-1634-1411
Indiana University School of MedicineGeorge Washington University · USMakerere University · UGUniversity of Connecticut · USUniversity of Louisville · USUniversity of Minnesota · US

Funding

Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2M
Acute vs. delayed iron therapy: effect on iron status, anemia and cognitionU01HD064698 · NICHD · UNIVERSITY OF MINNESOTA · PI JOHN, CHANDY C. · 2009 to 2013
$916k
Vaccine Development for Falciparum Malaria in Pregnant Women and Their OffspringK08AI100997 · NIAID · RHODE ISLAND HOSPITAL · PI MICHELOW, IAN C · 2013 to 2017
$788k
NIAID NIH HHS K08 AI100997NICHD NIH HHS U01 HD064698NINDS NIH HHS R01 NS055349
6 · The paper itself

Abstract

backgroundWe hypothesized that oxidative stress in Ugandan children with severe malaria is associated with mortality.

methodsWe evaluated biomarkers of oxidative stress in children with cerebral malaria (CM, n = 77) or severe malarial anemia (SMA, n = 79), who were enrolled in a randomized clinical trial of immediate vs delayed iron therapy, compared with community children (CC, n = 83). Associations between admission biomarkers and risk of death during hospitalization or risk of readmission within 6 months were analyzed.

resultsNine children with CM and none with SMA died during hospitalization. Children with CM or SMA had higher levels of heme oxygenase-1 (HO-1) (P < .001) and lower superoxide dismutase (SOD) activity than CC (P < .02). Children with CM had a higher risk of death with increasing HO-1 concentration (odds ratio [OR], 6.07 [95% confidence interval {CI}, 1.17-31.31]; P = .03) but a lower risk of death with increasing SOD activity (OR, 0.02 [95% CI, .001-.70]; P = .03). There were no associations between oxidative stress biomarkers on admission and risk of readmission within 6 months of enrollment.

conclusionsChildren with CM or SMA develop oxidative stress in response to severe malaria. Oxidative stress is associated with higher mortality in children with CM but not with SMA. CLINICAL TRIALS REGISTRATION: NCT01093989.

Indexed as

AnemiaMalaria, CerebralMalaria, FalciparumOxidative StressPatient ReadmissionBiomarkersChildHeme Oxygenase-1HumansInfantProspective StudiesRandomized Controlled Trials as TopicSuperoxide DismutaseUgandaBiomarkersHeme Oxygenase-1HMOX1 protein, humanSuperoxide Dismutasecerebral malariachildheme oxygenase-1malariamalondialdehydeoxidative stressPlasmodium falciparumsevere malarial anemiasuperoxide dismutase

Identifiers

PMID35678643
PMCPMC9890907
OpenAlexW4281628838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.