ArticleEnvironmental science. Processes & impacts2022
A food web bioaccumulation model for the accumulation of per- and polyfluoroalkyl substances (PFAS) in fish: how important is renal elimination?
Article in Environmental science. Processes & impacts, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Using Dose-Additive Models To Predict Exposure and Effects of a Military Site Risk-Relevant PFAS Mixture in Mice.ACS environmental Au · 2026Article
- PFAS Mixture Composition and Internal Exposure Profiles Shape Biological Responses under Field-Realistic Exposure.Environmental science & technology · 2026Article
- From industry to consumer use: unraveling PFAS sources, bioaccumulation, and fluxes in a year-long catchment monitoring study.Environmental geochemistry and health · 2026Article
- The influence of temperature and conductivity on metabolism and Per- and Polyfluoroalkyl Substance (PFAS) bioconcentration in Bluegill (Lepomis macrochirus).Ecotoxicology (London, England) · 2026Article
- Large declines in organofluorine contamination indicated by subarctic marine mammal tissues.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Non-target screening reveals 124 PFAS at an AFFF-impacted field site in Germany specified by novel systematic terminology.Analytical and bioanalytical chemistry · 2025Article
- PFC/PFAS concentrations in human milk and infant exposure through lactation: a comprehensive review of the scientific literature.Archives of toxicology · 2025Review
- Residual depletion of eugenol as an anesthetic in growing phase pacu (Piaractus mesopotamicus).Veterinary research communications · 2025Article
- Assessing Bivalves as Biomonitors of Per- and Polyfluoroalkyl Substances in Coastal Environments.Environmental science & technology · 2025Article
- Quantifying sources of variability in fish bioaccumulation factor estimates for perfluoro-n-octane sulfonic acid: study design effects and implications for water quality criteria.Environmental toxicology and chemistry · 2025Article
- Considerations and challenges in support of science and communication of fish consumption advisories for per- and polyfluoroalkyl substances.Integrated environmental assessment and management · 2024Review
- Characterizing the Areal Extent of PFAS Contamination in Fish Species Downgradient of AFFF Source Zones.Environmental science & technology · 2024Article
- Development and Evaluation of Aquatic and Terrestrial Food Web Bioaccumulation Models for Per- and Polyfluoroalkyl Substances.Environmental science & technology · 2024Article
- Assessing Per- and Polyfluoroalkyl Substances in Fish Fillet Using Non-Targeted Analyses.Environmental science & technology · 2024Article
- Predicting Bioaccumulation of Nanomaterials: Modeling Approaches with Challenges.Environment & health (Washington, D.C.) · 2024Review
- Associations of Serum Perfluoroalkyl Substances and Placental Human Chorionic Gonadotropin in Early Pregnancy, Measured in the UPSIDE Study in Rochester, New York.Environmental health perspectives · 2024Article
- Predicting the Accumulation of Ionizable Pharmaceuticals and Personal Care Products in Aquatic and Terrestrial Organisms.Environmental toxicology and chemistry · 2024Article
- Developing Methods for Assessing Trophic Magnification of Perfluoroalkyl Substances within an Urban Terrestrial Avian Food Web.Environmental science & technology · 2023Article
- Probing the Interactions of Perfluorocarboxylic Acids of Various Chain Lengths with Human Serum Albumin: Calorimetric and Spectroscopic Investigations.Chemical research in toxicology · 2023Article
- Biota-Sediment Accumulation Factors for Per- and Polyfluoroalkyl Substances.Environmental toxicology and chemistry · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Per- and polyfluoroalkyl substances (PFAS) are a large class of highly fluorinated anthropogenic chemicals. Some PFAS bioaccumulate in aquatic food webs, thereby posing risks for seafood consumers. Existing models for persistent organic pollutants (POPs) perform poorly for ionizable PFAS. Here we adapt a well-established food web bioaccumulation model for neutral POPs to predict the bioaccumulation behavior of six perfluoroalkyl acids (PFAAs) and two perfluoroalkyl ether acids (HFPO-DA, 9-Cl-PF3ONS) produced as PFAA replacements. The new model includes sorption to blood plasma proteins and phospholipids, empirically parameterized membrane transport, and renal elimination for PFAAs. Improved performance relative to prior models without these updates is shown by comparing simulations to field and lab measurements. PFAS with eight or more perfluorinated carbons (
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Registered trials
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