Evidence map›Paper›PMID 35678626›Full record

ArticleGlia2022

Cellular mechanisms mediating activity-dependent extracellular space shrinkage in the retina.

Pei-Pei Chiang, Sidney P Kuo, Eric A Newman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pei-Pei ChiangDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Sidney P KuoDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Eric A NewmanDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-9296-6237
University of Minnesota · US

Funding

Visual TestingP30EY011374 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NEWMAN, ERIC A · 1996 to 2019
$8.8M
Regulation of Capillary Blood Flow in the Retina in Health and in Diabetic RetinopathyR01EY026514 · NEI · UNIVERSITY OF MINNESOTA · PI NEWMAN, ERIC A · 2016 to 2020
$1.9M
Glial cell regulation of blood flow in capillariesR01EY026882 · NEI · UNIVERSITY OF MINNESOTA · PI NEWMAN, ERIC A · 2016 to 2020
$1.7M
NEI NIH HHS P30 EY011374NEI NIH HHS R01 EY026514NEI NIH HHS R01 EY026882
6 · The paper itself

Abstract

Volume transmission plays an essential role in CNS function, with neurotransmitters released from synapses diffusing through the extracellular space (ECS) to distant sites. Changes in the ECS volume fraction (α) will influence the diffusion and the concentration of transmitters within the ECS. We have recently shown that neuronal activity evoked by physiological photic stimuli results in rapid decreases in ECS α as large as 10% in the retina. We now characterize the cellular mechanisms responsible for this ECS shrinkage. We find that block of inwardly rectifying K

Indexed as

Extracellular SpaceNeurogliaBumetanideNeuronsPotassiumRetinaSodiumBumetanidePotassiumSodiumAQP4 channelsextracellular spaceglial cellsinwardly rectifying K+ channelsmonocarboxylate transporterMüller cellsNa+/HCO3− cotransporterNa+/K+/2Cl− cotransporterretina

Identifiers

PMID35678626
PMCPMC9378592
OpenAlexW4281728798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.