ArticleAngewandte Chemie (International ed. in English)2022
Reverse Sequence Polymerization-Induced Self-Assembly in Aqueous Media.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Time-Resolved SAXS Studies During the Synthesis of Hydrolytically Degradable Poly(ε-caprolactone)-Poly(N,N'-dimethylacrylamide) Diblock Copolymer Nanoparticles in Aqueous Media.Angewandte Chemie (International ed. in English) · 2026Article
- Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers.Materials (Basel, Switzerland) · 2024Review
- Synthesis of Poly(propylene oxide)-Poly(Macromolecules · 2024Article
- Polyphenol-based polymer nanoparticles for inhibiting amyloid protein aggregation: recent advances and perspectives.Frontiers in nutrition · 2024Review
- Fluorescence-readout as a powerful macromolecular characterisation tool.Chemical science · 2023Review
- Efficient Synthesis of Hydrolytically Degradable Block Copolymer Nanoparticles via Reverse Sequence Polymerization-Induced Self-Assembly in Aqueous Media.Angewandte Chemie (International ed. in English) · 2023Article
- Thermoresponsive Poly(Biomacromolecules · 2023Article
- Article
- Article
- Reverse Sequence Polymerization-Induced Self-Assembly in Aqueous Media.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
We report a new aqueous polymerization-induced self-assembly (PISA) formulation that enables the hydrophobic block to be prepared first when targeting diblock copolymer nano-objects. This counter-intuitive reverse sequence approach uses an ionic reversible addition-fragmentation chain transfer (RAFT) agent for the RAFT aqueous dispersion polymerization of 2-hydroxypropyl methacrylate (HPMA) to produce charge-stabilized latex particles. Chain extension using a water-soluble methacrylic, acrylic or acrylamide comonomer then produces sterically stabilized diblock copolymer nanoparticles in an aqueous one-pot formulation. In each case, the monomer diffuses into the PHPMA particles, which act as the locus for the polymerization. A remarkable change in morphology occurs as the ≈600 nm latex is converted into much smaller sterically stabilized diblock copolymer nanoparticles, which exhibit thermoresponsive behavior. Such reverse sequence PISA formulations enable the efficient synthesis of new functional diblock copolymer nanoparticles.
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Registered trials
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