ArticleeLife2022
Towards a unified model of naive T cell dynamics across the lifespan.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- The SATvac model of CD8+ T cell expansion and contraction phases considering memory and effector cell differentiation.PLoS computational biology · 2026Article
- Quorum sensing underlies the establishment and maintenance of marginal zone B cells.bioRxiv : the preprint server for biology · 2026Article
- What Do We Know About Immune System Aging from Human and Animal Studies?International journal of molecular sciences · 2026Review
- Immunological decoding of adult T cell leukemia - its cell of origin and oncogenesis.Biomarker research · 2026Review
- Limited roles of the miR-17-92 cluster in the regulation of T-cell apoptosis.The FEBS journal · 2026Article
- Is Thymic Involution Truly a Deterioration or an Adaptation?Bulletin of mathematical biology · 2026Article
- Identifying space-resolved proteins of the murine thymus, by combining MALDI-MSI and proteomics.Life science alliance · 2026Article
- Peripheral immune cell subsets as potential predictors of benefit from immune checkpoint blockade therapy in small cell lung cancer.Frontiers in immunology · 2026Article
- The cellular senescence-metabolism axis: emerging insights into T cell dynamics in the context of biological aging.Cell communication and signaling : CCS · 2025Review
- A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.Science immunology · 2025Article
- Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation.Cell research · 2025Article
- Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells.Discovery immunology · 2025Article
- The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.PLoS biology · 2024Article
- Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity.Life science alliance · 2024Article
- The dynamics and longevity of circulating CD4bioRxiv : the preprint server for biology · 2024Article
- Coronin 1-dependent cell density sensing and regulation of the peripheral T cell population size.Oxford open immunology · 2024Review
- Shaping immunity for life: Layered development of CD8Immunological reviews · 2023Review
- Modeling T Cell Fate.Annual review of immunology · 2023Review
- Quantifying cellular dynamics in mice using a novel fluorescent division reporter system.Frontiers in immunology · 2023Article
- Maintaining naivety of T cells.eLife · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Naive CD4 and CD8 T cells are cornerstones of adaptive immunity, but the dynamics of their establishment early in life and how their kinetics change as they mature following release from the thymus are poorly understood. Further, due to the diverse signals implicated in naive T cell survival, it has been a long-held and conceptually attractive view that they are sustained by active homeostatic control as thymic activity wanes. Here we use multiple modelling and experimental approaches to identify a unified model of naive CD4 and CD8 T cell population dynamics in mice, across their lifespan. We infer that both subsets divide rarely, and progressively increase their survival capacity with cell age. Strikingly, this simple model is able to describe naive CD4 T cell dynamics throughout life. In contrast, we find that newly generated naive CD8 T cells are lost more rapidly during the first 3-4 weeks of life, likely due to increased recruitment into memory. We find no evidence for elevated division rates in neonates, or for feedback regulation of naive T cell numbers at any age. We show how confronting mathematical models with diverse datasets can reveal a quantitative and remarkably simple picture of naive T cell dynamics in mice from birth into old age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.