Evidence map›Paper›PMID 35678361›Full record

ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2023

Brain regions associated with olfactory dysfunction in first episode psychosis patients.

Semra Etyemez, Zui Narita, Marina Mihaljevic, Jennifer M Coughlin, Gerald Nestadt, Frederick C Jr Nucifora, Thomas W Sedlak, Nicola G Cascella, Finn-Davis Batt, Jun Hua and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. [Depressive disorders and olfactory dysfunction].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Semra EtyemezDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zui NaritaDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marina MihaljevicDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jennifer M CoughlinDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gerald NestadtDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Frederick C Jr NuciforaDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Thomas W SedlakDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicola G CascellaDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Finn-Davis BattDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jun HuaRadiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andreia FariaRadiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Koko IshizukaDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vidyulata KamathDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kun YangDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Akira SawaDepartments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USKennedy Krieger Institute · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
High throughput marker for cognitive deficit: cellular autofluorescenceR01MH107730 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2018 to 2022
$3.0M
DISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8M
Oxidative stress and schizophrenia: combination of cell biology and brain imagingR01MH092443 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2015
$1.8M
NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH092443NIMH NIH HHS R01 MH105660NIMH NIH HHS R01 MH107730
6 · The paper itself

Abstract

objectivesOlfactory dysfunction is reproducibly reported in psychotic disorders, particularly in association with negative symptoms. The superior frontal gyrus (SFG) has been frequently studied in patients with psychotic disorders, in particular with their associations with negative symptoms. The relationship between olfactory functions and brain structure has been studied in healthy controls (HCs). Nevertheless, the studies with patients with psychotic disorders are limited. Here we report the olfactory-brain relationship in a first episode psychosis (FEP) cohort through both hypothesis-driven (centred on the SFG) and data-driven approaches.

methodsUsing data from 88 HCs and 76 FEP patients, we evaluated the correlation between olfactory functions and structural/resting-state functional magnetic resonance imaging (MRI) data.

resultsWe found a significant correlation between the left SFG volume and odour discrimination in FEP patients, but not in HCs. We also observed a significant correlation between rs-fMRI connectivity involving the left SFG and odour discrimination in FEP patients, but not in HCs. The data-driven approach didn't observe any significant correlations, possibly due to insufficient statistical power.

conclusionThe left SFG may be a promising brain region in the context of olfactory dysfunction and negative symptoms in FEP.

Indexed as

Olfaction DisordersPsychotic DisordersSchizophreniaBrainHumansMagnetic Resonance Imagingfirst episode psychosismagnet resonance imagingOlfactory dysfunctionschizophreniasuperior frontal gyrus

Identifiers

PMID35678361
PMCPMC10503825
OpenAlexW4281699430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.