Evidence map›Paper›PMID 35678297›Full record

ArticleJournal of clinical pharmacology2022

The Impact of Suboptimal 25-Hydroxyvitamin D Levels and Cholecalciferol Replacement on the Pharmacokinetics of Oral Midazolam in Control Subjects and Patients With Chronic Kidney Disease.

Stacey M Tuey, Linda Prebehalla, Amandla-Atilano Roque, Gavriel Roda, Michel B Chonchol, Nirav Shah, Michael F Wempe, Yichun Hu, Susan L Hogan, Thomas D Nolin and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The impact of progressive chronic kidney disease on hepatic drug metabolism.Drug metabolism and disposition: the biological fate of chemicals · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Stacey M TueySkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0003-0946-3506
Linda PrebehallaDepartment of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Amandla-Atilano RoqueSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
Gavriel RodaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
Michel B ChoncholDivision of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado, USA.
Nirav ShahDepartment of Medicine Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Michael F WempeSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
Yichun HuKidney Center and Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Susan L HoganKidney Center and Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Thomas D NolinDepartment of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4339-1382
Melanie S JoySkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
University of Colorado Anschutz Medical Campus · USUniversity of Pittsburgh · USUniversity of Colorado Hospital · USUniversity of North Carolina at Chapel Hill · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney DiseaseR01GM107122 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JOY, MELANIE S, NOLIN, THOMAS DOUGLAS · 2014 to 2018
$2.3M
NCATS NIH HHS UL1 TR001857NCATS NIH HHS UL1 TR002535NIGMS NIH HHS R01 GM107122
6 · The paper itself

Abstract

The aim of this study was to investigate the impact of suboptimal 25-hydroxyvitamin D (25-VitD) and cholecalciferol (VitD

Indexed as

CholecalciferolRenal Insufficiency, ChronicHumansMidazolamVitamin DVitamins25-hydroxyvitamin DCholecalciferolMidazolamVitamin DVitaminscholecalciferolchronic kidney diseaseCYP3A4metabolismmidazolampharmacokineticsvitamin D

Identifiers

PMID35678297
PMCPMC12121630
OpenAlexW4281779004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.