ArticleJournal of periodontology2023
Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats.
Article in Journal of periodontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Atomic-scale ordering enables intrinsic bioactivity and rapid osseointegration in medium-entropy alloys.Bioactive materials · 2026Article
- Protocol for spectrophotometric determination of titanium microparticles in biological samples via Ti(IV)-HSTAR protocols · 2026Article
- Histomorphometric Evaluation of Subchronic and Chronic Effects of Novel Experimental Calcium Aluminate- and Calcium Silicate-Based Dental Cement Materials on Rat Liver, Kidney, Brain, and Spleen Tissues.Journal of functional biomaterials · 2026Article
- Beyond Biocompatibility: Immune Dysregulation, Oxidative Stress, and Tissue Intolerance Associated with Ti-6Al-4V Dental Implants-A Critical Review and Perspective.Antioxidants (Basel, Switzerland) · 2026Review
- Immunological and tissue reactions to titanium particles generated by the mechanical decontamination of dental implants: In vitro and in vivo study.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Electrochemical Deposition and Characterisation of Silver-Containing Hydroxyapatite Coatings on Zinc: Influence of Silver Addition on the Functional Properties of a Biodegradable Implant System.International journal of biomaterials · 2026Article
- Biomaterial physicochemical properties govern immune activation and bone regeneration: a titanium-focused design-oriented osteoimmunological framework.Frontiers in immunology · 2026Review
- Effect of Tribocorrosion on Mechanical Behavior of Titanium Dental Implants: An In Vitro Study.Materials (Basel, Switzerland) · 2025Article
- Surface Analysis of Orthodontic Mini-Implants after Their Clinical Use.Journal of functional biomaterials · 2024Article
- Article
- Role of immune dysregulation in peri-implantitis.Frontiers in immunology · 2024Review
- Association between oxidative balance score and serum cobalt level in population with metal implants: a cross-sectional study from NHANES 2015-2020.Frontiers in nutrition · 2024Article
- Article
- Mechanical and Biological Characterization of PMMA/AlPolymers · 2023Article
- Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats.Journal of periodontology · 2023Article
- Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants.Scientific reports · 2022Article
- The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis.Journal of bone metabolism · 2022Article
- Osteoimmune regulation underlies oral implant osseointegration and its perturbation.Frontiers in immunology · 2022Review
- A SiOFrontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris.
methodsTwenty Sprague-Dawley rats were randomly distributed into three groups: an experimental group with a mandibular bone defect filled with metallic debris obtained by implantoplasty; a positive control group; and a negative control group. Thirty days after surgery, the rats were euthanized and perilesional tissue surrounding the mandibular defect was removed, together with the lungs, spleen, liver, and brain. Two blood samples were collected: immediately before surgery and before euthanasia. The perilesional tissue was histologically analyzed using hematoxylin-eosin staining, and Ti, aluminum, and vanadium ion concentrations in blood and organs were measured by TQ-ICP-MS. Descriptive and bivariate analyses of the data were performed.
resultsAll rats with implanted metal debris showed metal particles and a bone fracture callus on the osseous defect. The metal particles were surrounded by a foreign body reaction characterized by the presence of histiocytes and multinucleated giant cells (MNGCs). The experimental group had a significant higher concentration of Ti ions in all studied organs except lung tissue (p < 0.05). In addition, there were more V ions in the brain in the experimental group (p = 0.008).
conclusionsAlthough further studies are required to confirm the clinical relevance of these results, Ti metal particles in the jaw might increase the concentration of metal ions in vital organs and induce a foreign body reaction.
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