Evidence map›Paper›PMID 35678231›Full record

ArticleClinical and translational medicine2022

ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.

Aolin Li, Congcong Cao, Ying Gan, Xiaofei Wang, Tianyu Wu, Quan Zhang, Yuchen Liu, Lin Yao, Qian Zhang

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 41 citations in OpenAlex.

  1. Beyond mBiomedicines · 2026
    Review
  2. Review
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  4. Article
  5. Article
  6. Article
  7. Decoding mJournal of translational medicine · 2025
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  8. METTL3: a multifunctional regulator in diseases.Molecular and cellular biochemistry · 2025
    Review
  9. Article
  10. Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. RNA NNature reviews. Urology · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aolin LiDepartment of Urology, Peking University First Hospital, Beijing, China.
Congcong CaoGuangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Ying GanDepartment of Urology, Peking University First Hospital, Beijing, China.ORCID 0000-0001-8393-6768
Xiaofei WangDepartment of Urology, Peking University First Hospital, Beijing, China.
Tianyu WuDepartment of Urology, Peking University First Hospital, Beijing, China.
Quan ZhangDepartment of Urology, Peking University First Hospital, Beijing, China.
Yuchen LiuGuangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.ORCID 0000-0002-6517-0022
Lin YaoDepartment of Urology, Peking University First Hospital, Beijing, China.
Qian ZhangDepartment of Urology, Peking University First Hospital, Beijing, China.
Peking University · CNShenzhen Second People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies on biological functions of N6-methyladenosine (m

methodsThe expression of ZNF677 and its clinicopathological impact were evaluated in renal cell carcinoma (RCC) patients. The m

resultsZNF677 is frequently downregulated in RCC tissues and its low expression is associated with unfavourable prognosis and decreased m

conclusionZNF677 functions as a tumour suppressor and is frequently silenced via m

Indexed as

Carcinoma, Renal CellKidney NeoplasmsAdenosineCell Line, TumorCyclin-Dependent Kinase Inhibitor ProteinsDual-Specificity PhosphatasesHumansMethyltransferasesRNA-Binding ProteinsRNA, MessengerAdenosineCDKN3 protein, humanCyclin-Dependent Kinase Inhibitor ProteinsDual-Specificity PhosphatasesIGF2BP2 protein, humanMethyltransferasesMETTL3 protein, humanN-methyladenosineRNA-Binding ProteinsRNA, MessengerCDKN3dCas13bm6ARCCZNF677

Identifiers

PMID35678231
PMCPMC9178504
OpenAlexW4281695964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.