Evidence map›Paper›PMID 35678196›Full record

SynthesisJournal of diabetes investigation2022

Effects of whole grain intake on glycemic control: A meta-analysis of randomized controlled trials.

Zhiwei Li, Hongjia Yan, Liying Chen, Yixing Wang, Jingjing Liang, Xin Feng, Suocheng Hui, Kai Wang

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Rye (Frontiers in nutrition · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhiwei Li *Department of Respiratory and Critical Care Medicine, The General Hospital of Western Theater Command PLA, Beijing, China.
Hongjia Yan *Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liying ChenDepartment of Respiratory and Critical Care Medicine, Eighth Medical Center, PLA General Hospital, Chengdu, China.
Yixing WangDepartment of Research, The PLA Rocket Force Characteristic Medical Center, Beijing, China.
Jingjing LiangDepartment of Research, The PLA Rocket Force Characteristic Medical Center, Beijing, China.
Xin FengDepartment of Research, The PLA Rocket Force Characteristic Medical Center, Beijing, China.
Suocheng HuiDepartment of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Kai WangDepartment of Research, The PLA Rocket Force Characteristic Medical Center, Beijing, China.ORCID https://orcid.org/0000-0003-2649-3088

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionAlthough mounting evidence has suggested an inverse association between the intake of whole grains and glycemic control, findings from randomized controlled trials are still conflicting. The current study was carried out to evaluate the effect of medium/long-term whole grain intake on glycemic control in metabolic syndrome and healthy populations. MATERIALS AND

methodsA literature search was carried out to identify qualified studies up to July 2021. The effects of whole grain consumption on glycemic control were calculated using a fixed effects model. Subgroup analysis was used to study whether grouping factors were important influencing factors of heterogeneity between research results.

resultsA total of 32 randomized controlled trials with 2,060 participants were included in the analyses. Whole grain consumption showed a significant inverse regulatory effect on fasting glucose concentration, but no significant effect was found for other glycemic measures, such as fasting insulin, homeostatic model assessment for insulin resistance, glycated hemoglobin and 2-h glucose, in the pooled analysis. Through subgroup analyses, a significant decrease in fasting glucose concentration was observed for studies with a higher whole grain dose, with participants of normal glycemia, and with mixed types of whole grain.

conclusionsMedium-/long-term whole grain intake reduced the fasting glucose concentration compared with similar refined foods. Appropriate intervention dose and accurate population selection might be the key links for whole grain consumption to exert its glycemic control effect.

Indexed as

Blood GlucoseWhole GrainsGlycated HemoglobinHumansInsulinRandomized Controlled Trials as TopicBlood GlucoseGlycated HemoglobinInsulinGlucose controlInsulin sensitivityMeta-analysisWhole grain

Identifiers

PMID35678196
PMCPMC9623515

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.